| 1 | Gerrit Cole | NYY | 16 | 8 | 0 | 30 | 30 | 181.1 | 12.06 | 2.03 | 1.19 | .305 | 77.9% | 43.1% | 13.5% | 97.8 | 3.23 | 3.10 | 2.92 | 2.93 | 5.2 |
| 2 | Nathan Eovaldi | BOS | 11 | 9 | 0 | 32 | 32 | 182.1 | 9.63 | 1.73 | 0.74 | .326 | 70.4% | 42.0% | 8.2% | 97.1 | 3.75 | 3.35 | 2.79 | 3.48 | 5.7 |
| 3 | Dylan Cease | CHW | 13 | 7 | 0 | 32 | 32 | 165.2 | 12.28 | 3.69 | 1.09 | .309 | 73.9% | 33.3% | 11.3% | 96.8 | 3.91 | 3.65 | 3.41 | 3.72 | 4.4 |
| 4 | Shane McClanahan | TBR | 10 | 6 | 0 | 25 | 25 | 123.1 | 10.29 | 2.70 | 1.02 | .328 | 78.9% | 45.5% | 14.3% | 96.7 | 3.43 | 4.60 | 3.31 | 3.23 | 2.5 |
| 5 | Frankie Montas | OAK | 13 | 9 | 0 | 32 | 32 | 187.0 | 9.96 | 2.74 | 0.96 | .296 | 74.5% | 42.8% | 11.4% | 96.6 | 3.37 | 3.98 | 3.37 | 3.64 | 4.0 |
| 6 | Shohei Ohtani | LAA | 9 | 2 | 0 | 23 | 23 | 130.1 | 10.77 | 3.04 | 1.04 | .269 | 79.4% | 45.0% | 13.3% | 95.7 | 3.18 | 3.32 | 3.52 | 3.55 | 3.0 |
| 7 | Logan Gilbert | SEA | 6 | 5 | 0 | 24 | 24 | 119.1 | 9.65 | 2.11 | 1.28 | .293 | 67.9% | 32.3% | 10.9% | 95.4 | 4.68 | 4.09 | 3.73 | 4.19 | 2.2 |
| 8 | Taylor Hearn | TEX | 6 | 6 | 0 | 42 | 11 | 104.1 | 7.94 | 3.62 | 1.47 | .275 | 70.8% | 39.4% | 13.7% | 95.4 | 4.66 | 4.82 | 4.82 | 4.80 | 0.2 |
| 9 | Carlos Rodon | CHW | 13 | 5 | 0 | 24 | 24 | 132.2 | 12.55 | 2.44 | 0.88 | .267 | 82.2% | 37.7% | 9.6% | 95.4 | 2.37 | 2.68 | 2.65 | 3.17 | 4.9 |
| 10 | Yusei Kikuchi | SEA | 7 | 9 | 0 | 29 | 29 | 157.0 | 9.34 | 3.55 | 1.55 | .289 | 74.6% | 48.4% | 20.6% | 95.3 | 4.41 | 5.23 | 4.61 | 3.85 | 1.1 |
| 11 | Jorge Lopez | BAL | 3 | 14 | 0 | 33 | 25 | 121.2 | 8.28 | 4.14 | 1.55 | .340 | 70.0% | 50.4% | 20.0% | 95.2 | 6.07 | 5.44 | 5.20 | 4.48 | 0.8 |
| 12 | Nick Pivetta | BOS | 9 | 8 | 1 | 31 | 30 | 155.0 | 10.16 | 3.77 | 1.39 | .288 | 73.2% | 38.3% | 13.6% | 95.0 | 4.53 | 3.81 | 4.28 | 4.28 | 2.2 |
| 13 | Robbie Ray | TOR | 13 | 7 | 0 | 32 | 32 | 193.1 | 11.54 | 2.42 | 1.54 | .268 | 90.1% | 37.2% | 15.9% | 94.6 | 2.84 | 3.60 | 3.69 | 3.36 | 3.9 |
| 14 | Cal Quantrill | CLE | 8 | 3 | 0 | 40 | 22 | 149.2 | 7.28 | 2.83 | 0.96 | .267 | 80.0% | 43.2% | 10.7% | 94.6 | 2.89 | 4.01 | 4.07 | 4.43 | 2.0 |
| 15 | Tarik Skubal | DET | 8 | 12 | 0 | 31 | 29 | 149.1 | 9.88 | 2.83 | 2.11 | .277 | 81.4% | 38.5% | 20.5% | 94.5 | 4.34 | 5.58 | 5.09 | 4.06 | 0.6 |
| 16 | Garrett Richards | BOS | 7 | 8 | 3 | 40 | 22 | 136.2 | 7.57 | 3.95 | 1.25 | .333 | 69.8% | 47.0% | 13.7% | 94.5 | 4.87 | 5.58 | 4.72 | 4.71 | 1.0 |
| 17 | Jose Urena | DET | 4 | 8 | 0 | 26 | 18 | 100.2 | 5.99 | 3.75 | 1.25 | .319 | 65.3% | 52.0% | 14.7% | 94.5 | 5.81 | 5.88 | 5.02 | 4.87 | 0.3 |
| 18 | Brad Keller | KCR | 8 | 12 | 0 | 26 | 26 | 133.2 | 8.08 | 4.31 | 1.21 | .347 | 68.7% | 47.8% | 14.9% | 94.2 | 5.39 | 6.47 | 4.72 | 4.57 | 1.1 |
| 19 | Mike Foltynewicz | TEX | 2 | 12 | 0 | 28 | 24 | 139.0 | 6.28 | 2.33 | 2.27 | .254 | 72.6% | 37.6% | 19.2% | 94.2 | 5.44 | 5.30 | 6.02 | 5.06 | -0.7 |
| 20 | Jose Berrios | - - - | 12 | 9 | 0 | 32 | 32 | 192.0 | 9.56 | 2.11 | 1.03 | .277 | 72.3% | 42.8% | 12.6% | 94.1 | 3.52 | 4.09 | 3.47 | 3.59 | 4.0 |
| 21 | Casey Mize | DET | 7 | 9 | 0 | 30 | 30 | 150.1 | 7.06 | 2.45 | 1.44 | .254 | 79.5% | 48.1% | 16.2% | 94.1 | 3.71 | 4.92 | 4.71 | 4.37 | 1.2 |
| 22 | Jameson Taillon | NYY | 8 | 6 | 0 | 29 | 29 | 144.1 | 8.73 | 2.74 | 1.50 | .272 | 73.1% | 33.2% | 12.1% | 94.1 | 4.30 | 3.89 | 4.43 | 4.69 | 1.9 |
| 23 | Lance Lynn | CHW | 11 | 6 | 0 | 28 | 28 | 157.0 | 10.09 | 2.58 | 1.03 | .263 | 81.5% | 38.1% | 10.2% | 94.0 | 2.69 | 2.72 | 3.32 | 3.82 | 4.2 |
| 24 | Michael Wacha | TBR | 3 | 5 | 0 | 29 | 23 | 124.2 | 8.74 | 2.24 | 1.66 | .312 | 69.7% | 39.5% | 17.7% | 94.0 | 5.05 | 5.51 | 4.47 | 3.91 | 1.1 |
| 25 | Lucas Giolito | CHW | 11 | 9 | 0 | 31 | 31 | 178.2 | 10.13 | 2.62 | 1.36 | .269 | 77.5% | 33.2% | 13.8% | 94.0 | 3.53 | 3.27 | 3.79 | 3.75 | 4.1 |
| 26 | Cristian Javier | HOU | 4 | 1 | 2 | 36 | 9 | 101.1 | 11.55 | 4.71 | 1.42 | .234 | 82.2% | 27.6% | 14.2% | 93.7 | 3.55 | 4.57 | 4.43 | 4.35 | 0.7 |
| 27 | Brady Singer | KCR | 5 | 10 | 0 | 27 | 27 | 128.1 | 9.19 | 3.72 | 0.98 | .350 | 67.8% | 49.9% | 13.0% | 93.7 | 4.91 | 4.54 | 4.04 | 4.11 | 2.0 |
| 28 | Matt Harvey | BAL | 6 | 14 | 0 | 28 | 28 | 127.2 | 6.70 | 2.61 | 1.34 | .331 | 60.4% | 42.7% | 12.3% | 93.6 | 6.27 | 5.37 | 4.60 | 4.81 | 1.9 |
| 29 | Martin Perez | BOS | 7 | 8 | 0 | 36 | 22 | 114.0 | 7.66 | 2.84 | 1.50 | .336 | 71.2% | 43.6% | 16.1% | 93.6 | 4.74 | 5.54 | 4.82 | 4.48 | 0.6 |
| 30 | Alek Manoah | TOR | 9 | 2 | 0 | 20 | 20 | 111.2 | 10.24 | 3.22 | 0.97 | .246 | 76.6% | 38.8% | 10.7% | 93.5 | 3.22 | 3.30 | 3.80 | 4.17 | 2.0 |