| 1 | Nathan Eovaldi | BOS | 11 | 9 | 0 | 32 | 32 | 182.1 | 9.63 | 1.73 | 0.74 | .326 | 70.4% | 42.0% | 8.2% | 97.1 | 3.75 | 3.35 | 2.79 | 3.48 | 5.7 |
| 2 | Sean Manaea | OAK | 11 | 10 | 0 | 32 | 32 | 179.1 | 9.74 | 2.06 | 1.25 | .318 | 77.3% | 42.0% | 13.8% | | 3.91 | 4.12 | 3.66 | 3.62 | 3.2 |
| 3 | Dylan Cease | CHW | 13 | 7 | 0 | 32 | 32 | 165.2 | 12.28 | 3.69 | 1.09 | .309 | 73.9% | 33.3% | 11.3% | 96.8 | 3.91 | 3.65 | 3.41 | 3.72 | 4.4 |
| 4 | Dallas Keuchel | CHW | 9 | 9 | 0 | 32 | 30 | 162.0 | 5.28 | 3.28 | 1.39 | .307 | 68.2% | 54.9% | 17.9% | 89.1 | 5.28 | 6.15 | 5.23 | 4.74 | 0.7 |
| 5 | Gerrit Cole | NYY | 16 | 8 | 0 | 30 | 30 | 181.1 | 12.06 | 2.03 | 1.19 | .305 | 77.9% | 43.1% | 13.5% | 97.8 | 3.23 | 3.10 | 2.92 | 2.93 | 5.2 |
| 6 | Cole Irvin | OAK | 10 | 15 | 0 | 32 | 32 | 178.1 | 6.31 | 2.12 | 1.16 | .302 | 71.1% | 37.6% | 10.4% | 91.0 | 4.24 | 4.92 | 4.30 | 4.82 | 2.0 |
| 7 | Chris Flexen | SEA | 14 | 6 | 0 | 31 | 31 | 179.2 | 6.26 | 2.00 | 0.95 | .300 | 76.6% | 42.4% | 9.1% | 92.9 | 3.61 | 4.27 | 3.89 | 4.56 | 3.0 |
| 8 | Jordan Lyles | TEX | 10 | 13 | 0 | 32 | 30 | 180.0 | 7.30 | 2.80 | 1.90 | .299 | 75.1% | 37.6% | 17.4% | 93.3 | 5.15 | 5.37 | 5.34 | 4.73 | 0.1 |
| 9 | Frankie Montas | OAK | 13 | 9 | 0 | 32 | 32 | 187.0 | 9.96 | 2.74 | 0.96 | .296 | 74.5% | 42.8% | 11.4% | 96.6 | 3.37 | 3.98 | 3.37 | 3.64 | 4.0 |
| 10 | Hyun-Jin Ryu | TOR | 14 | 10 | 0 | 31 | 31 | 169.0 | 7.62 | 1.97 | 1.28 | .295 | 70.7% | 46.8% | 14.1% | 89.8 | 4.37 | 4.45 | 4.02 | 3.94 | 2.5 |
| 11 | Jose Berrios | - - - | 12 | 9 | 0 | 32 | 32 | 192.0 | 9.56 | 2.11 | 1.03 | .277 | 72.3% | 42.8% | 12.6% | 94.1 | 3.52 | 4.09 | 3.47 | 3.59 | 4.0 |
| 12 | Lance McCullers Jr. | HOU | 13 | 5 | 0 | 28 | 28 | 162.1 | 10.26 | 4.21 | 0.72 | .273 | 78.5% | 56.4% | 11.7% | 93.4 | 3.16 | 3.37 | 3.52 | 3.69 | 3.2 |
| 13 | Lucas Giolito | CHW | 11 | 9 | 0 | 31 | 31 | 178.2 | 10.13 | 2.62 | 1.36 | .269 | 77.5% | 33.2% | 13.8% | 94.0 | 3.53 | 3.27 | 3.79 | 3.75 | 4.1 |
| 14 | Robbie Ray | TOR | 13 | 7 | 0 | 32 | 32 | 193.1 | 11.54 | 2.42 | 1.54 | .268 | 90.1% | 37.2% | 15.9% | 94.6 | 2.84 | 3.60 | 3.69 | 3.36 | 3.9 |
| 15 | Zack Greinke | HOU | 11 | 6 | 0 | 30 | 29 | 171.0 | 6.32 | 1.89 | 1.58 | .263 | 75.0% | 44.4% | 17.4% | 89.0 | 4.16 | 4.35 | 4.71 | 4.21 | 1.3 |