| 1 | David Riske | 16 | 11 | 16 | 275 | 0 | 303.1 | 8.96 | 3.83 | 1.25 | .259 | 81.5% | 37.4% | 12.4% | | 3.32 | | 4.26 | 4.02 | 1.6 |
| 2 | Rafael Betancourt | 19 | 16 | 12 | 273 | 0 | 308.1 | 9.14 | 1.98 | 0.82 | .280 | 77.5% | 29.3% | 6.8% | 92.0 | 2.80 | | 2.93 | 3.59 | 7.7 |
| 3 | Bob Wickman | 7 | 13 | 125 | 229 | 0 | 221.2 | 7.55 | 2.68 | 0.85 | .304 | 78.7% | 48.4% | 12.4% | | 3.21 | | 3.58 | 3.84 | 3.0 |
| 4 | CC Sabathia | 100 | 63 | 0 | 219 | 219 | 1406.1 | 7.31 | 2.97 | 0.84 | .290 | 71.8% | 44.0% | 8.6% | 94.1 | 3.83 | | 3.74 | 3.95 | 27.5 |
| 5 | Jake Westbrook | 62 | 60 | 0 | 192 | 153 | 1029.0 | 4.92 | 2.77 | 0.76 | .300 | 68.5% | 59.6% | 12.1% | 83.1 | 4.29 | | 4.13 | 4.01 | 13.1 |
| 6 | Danys Baez | 17 | 23 | 31 | 155 | 26 | 291.1 | 7.66 | 3.86 | 0.86 | .279 | 71.5% | 42.0% | 9.0% | | 3.92 | | 3.99 | 4.33 | 3.6 |
| 7 | Cliff Lee | 54 | 36 | 0 | 129 | 125 | 741.2 | 6.66 | 3.09 | 1.27 | .289 | 69.6% | 34.3% | 9.8% | 89.8 | 4.64 | | 4.59 | 4.77 | 8.1 |
| 8 | Bob Howry | 11 | 6 | 3 | 116 | 0 | 115.2 | 6.77 | 2.18 | 0.70 | .234 | 76.4% | 36.7% | 6.8% | | 2.57 | | 3.32 | 3.91 | 1.8 |
| 9 | Jason Davis | 18 | 22 | 1 | 114 | 52 | 401.1 | 5.43 | 3.25 | 0.99 | .310 | 67.8% | 49.0% | 10.8% | | 4.69 | | 4.49 | 4.53 | 3.5 |
| 10 | Ricardo Rincon | 3 | 5 | 2 | 113 | 0 | 89.2 | 8.03 | 2.91 | 0.60 | .288 | 69.9% | 48.6% | 8.1% | | 3.61 | | 3.10 | 3.48 | 1.7 |
| 11 | Matt Miller | 6 | 1 | 2 | 96 | 0 | 101.2 | 7.97 | 3.72 | 0.35 | .273 | 77.2% | 55.2% | 5.4% | | 2.74 | | 3.36 | 3.88 | 1.6 |
| 12 | Fernando Cabrera | 6 | 6 | 0 | 94 | 0 | 130.1 | 10.01 | 4.56 | 1.38 | .302 | 74.5% | 34.5% | 14.2% | 91.2 | 4.35 | | 4.45 | 3.92 | 0.1 |
| 13 | Paul Shuey | 8 | 3 | 2 | 86 | 0 | 91.2 | 10.70 | 3.53 | 0.20 | .333 | 71.9% | 61.9% | 5.0% | | 2.65 | | 2.13 | 2.42 | 2.9 |
| 14 | Scott Sauerbeck | 1 | 1 | 0 | 82 | 0 | 48.2 | 8.51 | 4.62 | 1.11 | .288 | 71.6% | 46.3% | 14.3% | | 4.62 | | 4.62 | 4.21 | -0.1 |
| 15 | Roberto Hernandez | 20 | 18 | 0 | 70 | 39 | 289.2 | 6.06 | 2.86 | 0.78 | .295 | 75.4% | 63.1% | 12.0% | 92.6 | 3.67 | | 4.13 | 3.95 | 3.7 |
| 16 | Joe Borowski | 4 | 5 | 45 | 69 | 0 | 65.2 | 7.95 | 2.33 | 1.23 | .330 | 68.3% | 33.7% | 9.7% | 88.6 | 5.07 | | 4.12 | 4.12 | 0.6 |
| 17 | Tom Mastny | 7 | 3 | 5 | 66 | 0 | 74.0 | 8.03 | 4.86 | 0.85 | .333 | 73.3% | 42.0% | 8.3% | 89.3 | 4.86 | | 4.41 | 4.63 | 0.2 |
| 18 | Mark Wohlers | 3 | 4 | 7 | 64 | 0 | 71.1 | 5.80 | 3.28 | 0.76 | .291 | 64.4% | 54.4% | 10.0% | | 4.79 | | 3.99 | 4.06 | 0.4 |
| 19 | Paul Byrd | 25 | 17 | 0 | 62 | 62 | 371.1 | 4.27 | 1.60 | 1.28 | .314 | 67.8% | 38.4% | 10.0% | 85.8 | 4.73 | | 4.73 | 4.77 | 3.5 |
| 20 | Rafael Perez | 1 | 2 | 1 | 62 | 0 | 73.0 | 9.49 | 2.59 | 0.86 | .235 | 82.0% | 53.4% | 12.1% | 89.3 | 2.22 | | 3.22 | 3.00 | 1.3 |
| 21 | Terry Mulholland | 6 | 6 | 0 | 61 | 6 | 146.0 | 3.88 | 3.14 | 1.36 | .297 | 72.3% | 42.9% | 11.8% | | 4.81 | | 5.36 | 5.24 | -0.7 |
| 22 | Rick White | 5 | 5 | 1 | 59 | 0 | 78.1 | 5.06 | 3.33 | 1.72 | .292 | 68.4% | 49.6% | 19.2% | | 5.29 | | 5.60 | 4.56 | -0.9 |
| 23 | Rich Rodriguez | 2 | 2 | 0 | 53 | 0 | 39.0 | 7.15 | 3.92 | 0.46 | .320 | 62.9% | | | | 4.15 | | 3.59 | | 0.5 |
| 24 | Scott Elarton | 14 | 14 | 0 | 52 | 52 | 299.0 | 5.51 | 2.71 | 1.72 | .256 | 74.0% | 32.8% | 12.6% | | 4.58 | | 5.29 | 4.95 | 0.9 |
| 25 | Bartolo Colon | 24 | 16 | 0 | 50 | 50 | 338.2 | 7.33 | 3.22 | 0.98 | .294 | 77.0% | 43.6% | 8.3% | | 3.56 | | 3.92 | 4.10 | 6.0 |
| 26 | Aaron Fultz | 4 | 3 | 0 | 49 | 0 | 37.0 | 6.81 | 4.38 | 0.49 | .266 | 80.5% | 35.1% | 4.2% | 82.2 | 2.92 | | 3.97 | 4.89 | 0.3 |
| 27 | Arthur Rhodes | 3 | 1 | 0 | 47 | 0 | 43.1 | 8.93 | 2.49 | 0.42 | .265 | 76.4% | 40.7% | 4.7% | | 2.08 | | 2.54 | 3.30 | 1.2 |
| 28 | Dave Burba | 11 | 10 | 0 | 44 | 30 | 184.2 | 6.97 | 3.46 | 0.93 | .336 | 60.6% | 45.6% | 8.3% | | 5.90 | | 4.06 | 4.64 | 2.7 |
| 29 | Jack Cressend | 2 | 2 | 0 | 44 | 0 | 58.2 | 5.52 | 2.91 | 0.77 | .300 | 78.9% | 37.6% | 7.1% | | 3.53 | | 3.99 | 4.62 | 0.4 |
| 30 | Jason Boyd | 3 | 1 | 0 | 44 | 0 | 52.1 | 5.33 | 4.47 | 0.69 | .217 | 68.4% | 46.2% | 7.5% | | 4.30 | | 4.50 | 4.99 | 0.1 |