| 1 | Dan Haren | 43 | 34 | 0 | 102 | 102 | 662.2 | 7.21 | 2.08 | 1.10 | .288 | 73.5% | 45.4% | 11.3% | 91.0 | 3.64 | | 3.90 | 3.76 | 12.2 |
| 2 | Joe Blanton | 47 | 46 | 0 | 119 | 118 | 752.2 | 5.08 | 2.39 | 0.81 | .296 | 69.5% | 45.3% | 7.7% | 89.3 | 4.23 | | 4.04 | 4.44 | 12.2 |
| 3 | Rich Harden | 20 | 8 | 0 | 51 | 45 | 277.1 | 9.38 | 3.60 | 0.65 | .259 | 77.6% | 39.0% | 7.6% | 93.1 | 2.76 | | 3.19 | 3.53 | 7.0 |
| 4 | Huston Street | 21 | 12 | 94 | 247 | 0 | 269.0 | 9.07 | 2.61 | 0.60 | .270 | 74.3% | 39.0% | 6.1% | 90.5 | 2.88 | | 2.90 | 3.51 | 6.6 |
| 5 | Justin Duchscherer | 22 | 16 | 14 | 157 | 22 | 299.1 | 7.34 | 2.10 | 0.75 | .259 | 78.6% | 41.5% | 7.8% | 86.4 | 2.65 | | 3.38 | 3.74 | 5.6 |
| 6 | Barry Zito | 30 | 23 | 0 | 69 | 69 | 449.1 | 6.45 | 3.77 | 1.06 | .262 | 75.6% | 39.6% | 9.6% | | 3.85 | | 4.61 | 4.78 | 5.2 |
| 7 | Chad Gaudin | 20 | 18 | 2 | 115 | 40 | 326.0 | 6.46 | 4.39 | 0.83 | .292 | 73.4% | 46.9% | 8.7% | 91.2 | 4.00 | | 4.54 | 4.73 | 2.6 |
| 8 | Esteban Loaiza | 12 | 9 | 0 | 28 | 28 | 169.1 | 5.42 | 2.34 | 0.96 | .302 | 67.2% | 40.2% | 8.1% | 87.1 | 4.62 | | 4.20 | 4.63 | 2.6 |
| 9 | Kiko Calero | 8 | 8 | 4 | 179 | 0 | 159.0 | 8.89 | 3.74 | 0.74 | .300 | 72.9% | 33.9% | 6.4% | 88.9 | 3.96 | | 3.52 | 4.18 | 2.5 |
| 10 | Dana Eveland | 9 | 9 | 0 | 29 | 29 | 168.0 | 6.32 | 4.13 | 0.54 | .312 | 72.5% | 48.7% | 6.6% | 91.5 | 4.34 | | 4.09 | 4.51 | 2.2 |
| 11 | Joe Kennedy | 11 | 15 | 1 | 85 | 24 | 196.2 | 5.31 | 3.71 | 0.82 | .296 | 73.8% | 46.9% | 8.0% | 88.4 | 4.03 | | 4.51 | 4.82 | 1.9 |
| 12 | Joey Devine | 6 | 1 | 1 | 42 | 0 | 45.2 | 9.66 | 2.96 | 0.00 | .217 | 81.6% | 38.8% | 0.0% | 94.0 | 0.59 | | 1.97 | 3.24 | 1.5 |
| 13 | Dallas Braden | 6 | 12 | 0 | 39 | 24 | 144.0 | 6.00 | 3.19 | 1.06 | .325 | 64.3% | 37.7% | 8.1% | 87.9 | 5.44 | | 4.53 | 4.86 | 1.4 |
| 14 | Greg Smith | 7 | 16 | 0 | 32 | 32 | 190.1 | 5.25 | 4.11 | 0.99 | .256 | 72.7% | 34.2% | 7.9% | 88.4 | 4.16 | | 4.82 | 5.23 | 1.4 |
| 15 | Kirk Saarloos | 18 | 16 | 2 | 72 | 44 | 307.1 | 3.43 | 3.25 | 0.94 | .302 | 73.1% | 55.3% | 12.1% | 87.2 | 4.51 | | 4.89 | 4.73 | 1.3 |
| 16 | Alan Embree | 3 | 7 | 17 | 138 | 0 | 129.2 | 7.50 | 3.40 | 0.90 | .296 | 69.9% | 38.9% | 7.5% | 93.8 | 4.44 | | 4.01 | 4.41 | 1.1 |
| 17 | Santiago Casilla | 5 | 2 | 4 | 102 | 0 | 106.1 | 8.29 | 3.89 | 0.93 | .309 | 74.9% | 38.4% | 8.1% | 94.8 | 4.32 | | 4.09 | 4.39 | 0.7 |
| 18 | Andrew Brown | 4 | 3 | 0 | 64 | 0 | 76.2 | 8.33 | 4.46 | 0.47 | .274 | 70.8% | 38.3% | 4.3% | 93.9 | 3.87 | | 3.66 | 4.56 | 0.7 |
| 19 | Josh Outman | 1 | 2 | 0 | 6 | 4 | 25.2 | 6.66 | 2.81 | 0.35 | .384 | 70.4% | 39.5% | 2.9% | 94.5 | 4.56 | | 3.33 | 4.57 | 0.6 |
| 20 | Brad Ziegler | 3 | 0 | 11 | 47 | 0 | 59.2 | 4.53 | 3.32 | 0.30 | .259 | 92.3% | 64.7% | 6.3% | 85.9 | 1.06 | | 3.72 | 3.99 | 0.5 |
| 21 | Jerry Blevins | 1 | 4 | 0 | 42 | 0 | 42.1 | 8.08 | 3.19 | 0.64 | .303 | 70.6% | 37.9% | 5.7% | 91.8 | 3.83 | | 3.55 | 4.26 | 0.5 |
| 22 | Lenny DiNardo | 9 | 12 | 0 | 46 | 22 | 154.1 | 4.14 | 3.67 | 0.93 | .294 | 66.3% | 55.8% | 12.1% | 81.6 | 4.61 | | 4.97 | 4.71 | 0.3 |
| 23 | Ron Flores | 1 | 4 | 1 | 53 | 0 | 56.0 | 6.59 | 3.54 | 0.96 | .274 | 82.3% | 28.7% | 6.2% | 85.9 | 3.05 | | 4.26 | 5.21 | 0.3 |
| 24 | Sean Gallagher | 2 | 3 | 0 | 11 | 11 | 56.2 | 8.58 | 5.72 | 1.11 | .317 | 63.5% | 27.2% | 8.6% | 92.6 | 5.88 | | 4.84 | 5.12 | 0.2 |
| 25 | Ruddy Lugo | 4 | 0 | 0 | 27 | 0 | 37.2 | 6.21 | 5.73 | 0.24 | .263 | 70.1% | 49.6% | 3.0% | 92.1 | 4.30 | | 4.28 | 5.03 | 0.1 |
| 26 | Brad Halsey | 5 | 4 | 0 | 52 | 7 | 94.1 | 5.06 | 4.39 | 1.05 | .307 | 73.8% | 43.9% | 9.1% | | 4.67 | | 5.16 | 5.45 | 0.1 |
| 27 | Seth Etherton | 1 | 1 | 0 | 3 | 3 | 17.2 | 5.09 | 2.55 | 2.04 | .218 | 51.9% | 20.3% | 12.9% | | 6.62 | | 5.68 | 5.16 | 0.1 |
| 28 | Jason Windsor | 0 | 1 | 0 | 4 | 3 | 13.2 | 3.95 | 3.29 | 1.32 | .365 | 60.3% | 40.4% | 10.5% | | 6.59 | | 5.27 | 5.32 | 0.0 |
| 29 | Matt Roney | 0 | 1 | 0 | 3 | 0 | 4.0 | 0.00 | 2.25 | 0.00 | .294 | 66.7% | 18.8% | 0.0% | | 4.50 | | 3.90 | 6.36 | 0.0 |
| 30 | Jay Witasick | 3 | 1 | 1 | 64 | 0 | 65.1 | 9.09 | 6.47 | 0.83 | .326 | 72.7% | 41.9% | 10.0% | 90.1 | 4.55 | | 4.68 | 4.72 | 0.0 |