| 1 | Zack Greinke | 26 | 22 | 0 | 66 | 66 | 449.1 | 8.47 | 2.12 | 0.58 | .304 | 72.0% | 43.2% | 6.0% | 93.9 | 3.14 | | 2.83 | 3.34 | 13.6 |
| 2 | Luke Hochevar | 24 | 30 | 0 | 74 | 73 | 444.0 | 6.28 | 2.94 | 1.11 | .298 | 63.5% | 47.8% | 11.6% | 93.1 | 5.31 | | 4.38 | 4.13 | 4.8 |
| 3 | Joakim Soria | 9 | 9 | 101 | 173 | 0 | 179.0 | 10.06 | 2.46 | 0.80 | .296 | 82.3% | 43.0% | 8.7% | 92.0 | 2.66 | | 2.92 | 3.04 | 4.4 |
| 4 | Kyle Davies | 17 | 30 | 0 | 67 | 67 | 368.0 | 6.41 | 4.21 | 1.10 | .317 | 66.4% | 40.9% | 9.3% | 92.6 | 5.55 | | 4.73 | 4.80 | 2.7 |
| 5 | Bruce Chen | 25 | 21 | 1 | 75 | 57 | 357.2 | 6.04 | 3.32 | 1.18 | .284 | 73.9% | 33.7% | 8.8% | 87.5 | 4.28 | | 4.65 | 4.82 | 2.6 |
| 6 | Felipe Paulino | 4 | 6 | 0 | 21 | 20 | 124.2 | 8.59 | 3.47 | 0.72 | .327 | 70.9% | 45.1% | 7.9% | 95.9 | 4.11 | | 3.51 | 3.74 | 2.5 |
| 7 | Brian Bannister | 14 | 24 | 0 | 50 | 49 | 281.2 | 5.59 | 3.20 | 1.21 | .302 | 64.4% | 46.6% | 11.4% | 89.7 | 5.46 | | 4.74 | 4.48 | 2.1 |
| 8 | Greg Holland | 5 | 2 | 4 | 61 | 0 | 78.2 | 11.10 | 3.09 | 0.69 | .286 | 75.4% | 41.9% | 7.9% | 95.7 | 2.97 | | 2.63 | 2.84 | 1.8 |
| 9 | Robinson Tejeda | 7 | 8 | 0 | 98 | 6 | 142.0 | 9.19 | 5.01 | 0.70 | .269 | 73.0% | 30.3% | 5.9% | 93.9 | 3.68 | | 3.78 | 4.45 | 1.7 |
| 10 | Jeff Francis | 6 | 16 | 0 | 31 | 31 | 183.0 | 4.48 | 1.92 | 0.93 | .316 | 68.8% | 47.1% | 8.5% | | 4.82 | | 4.10 | 4.29 | 1.7 |
| 11 | Kyle Farnsworth | 4 | 5 | 0 | 78 | 0 | 82.0 | 8.56 | 2.85 | 0.55 | .326 | 73.8% | 44.1% | 6.3% | 96.9 | 3.40 | | 3.11 | 3.55 | 1.2 |
| 12 | Gil Meche | 6 | 15 | 0 | 43 | 32 | 190.2 | 6.42 | 4.53 | 1.23 | .306 | 68.3% | 47.5% | 12.0% | 92.9 | 5.29 | | 5.03 | 4.71 | 0.7 |
| 13 | Danny Duffy | 4 | 8 | 0 | 20 | 20 | 105.1 | 7.43 | 4.36 | 1.28 | .329 | 70.8% | 37.5% | 11.5% | 94.0 | 5.64 | | 4.82 | 4.53 | 0.6 |
| 14 | Sidney Ponson | 1 | 7 | 0 | 14 | 9 | 58.2 | 4.91 | 3.84 | 0.92 | .351 | 57.4% | 49.3% | 10.0% | 91.7 | 7.36 | | 4.72 | 4.73 | 0.4 |
| 15 | Philip Humber | 2 | 1 | 0 | 8 | 1 | 21.2 | 6.65 | 2.91 | 0.42 | .304 | 69.9% | 45.7% | 3.8% | 91.5 | 4.15 | | 3.31 | 4.17 | 0.3 |
| 16 | Louis Coleman | 1 | 4 | 1 | 48 | 0 | 59.2 | 9.65 | 3.92 | 1.36 | .246 | 87.7% | 30.4% | 10.7% | 90.2 | 2.87 | | 4.30 | 4.11 | 0.2 |
| 17 | Aaron Crow | 4 | 4 | 0 | 57 | 0 | 62.0 | 9.44 | 4.50 | 1.16 | .290 | 88.2% | 52.1% | 17.8% | 95.9 | 2.76 | | 4.11 | 3.34 | 0.1 |
| 18 | Dusty Hughes | 1 | 5 | 0 | 65 | 1 | 70.1 | 6.27 | 4.09 | 0.64 | .302 | 71.2% | 37.6% | 5.3% | 90.4 | 4.09 | | 4.28 | 5.00 | 0.1 |
| 19 | Blake Wood | 6 | 6 | 1 | 106 | 0 | 119.1 | 7.01 | 4.07 | 0.83 | .302 | 73.2% | 52.3% | 9.6% | 96.3 | 4.30 | | 4.14 | 4.13 | 0.1 |
| 20 | Kanekoa Texeira | 1 | 0 | 0 | 33 | 0 | 49.0 | 3.49 | 3.31 | 0.55 | .333 | 72.7% | 54.2% | 5.9% | | 4.41 | | 4.32 | 4.80 | 0.1 |
| 21 | Juan Cruz | 3 | 4 | 2 | 51 | 0 | 55.2 | 7.28 | 5.34 | 0.97 | .302 | 65.8% | 24.7% | 7.1% | 94.5 | 5.50 | | 4.71 | 5.28 | 0.0 |
| 22 | Carlos Rosa | 0 | 0 | 1 | 7 | 0 | 10.2 | 3.38 | 2.53 | 0.84 | .257 | 77.6% | 47.2% | 9.1% | 94.2 | 3.38 | | 4.41 | 4.54 | 0.0 |
| 23 | Mitch Maier | 0 | 0 | 0 | 1 | 0 | 1.0 | 0.00 | 0.00 | 0.00 | .250 | 100.0% | 25.0% | 0.0% | 76.6 | 0.00 | | 3.03 | 5.54 | 0.0 |
| 24 | Bryan Bullington | 1 | 4 | 0 | 13 | 5 | 42.2 | 6.12 | 3.59 | 1.27 | .321 | 67.6% | 46.2% | 11.5% | 92.1 | 6.12 | | 5.02 | 4.68 | 0.0 |
| 25 | Nate Adcock | 1 | 1 | 1 | 24 | 3 | 60.1 | 5.37 | 3.88 | 0.75 | .297 | 68.2% | 55.6% | 10.0% | 91.0 | 4.62 | | 4.35 | 4.32 | 0.0 |
| 26 | Jeremy Jeffress | 1 | 1 | 1 | 14 | 0 | 15.1 | 7.63 | 6.46 | 0.59 | .262 | 69.4% | 56.1% | 7.7% | 97.5 | 4.70 | | 4.33 | 4.55 | -0.1 |
| 27 | Lenny DiNardo | 0 | 3 | 0 | 5 | 5 | 21.1 | 3.38 | 6.33 | 0.84 | .429 | 53.5% | 57.0% | 9.5% | 84.3 | 10.13 | | 5.82 | 5.89 | -0.1 |
| 28 | Horacio Ramirez | 0 | 2 | 0 | 19 | 1 | 22.2 | 5.16 | 4.37 | 1.19 | .312 | 65.1% | 42.3% | 9.7% | 90.3 | 5.96 | | 5.13 | 5.20 | -0.1 |
| 29 | Josh Rupe | 1 | 1 | 0 | 11 | 0 | 9.2 | 7.45 | 6.52 | 0.93 | .394 | 76.5% | 46.9% | 14.3% | 95.3 | 5.59 | | 4.94 | 4.48 | -0.1 |
| 30 | Doug Waechter | 0 | 0 | 0 | 5 | 0 | 5.1 | 5.06 | 5.06 | 3.38 | .350 | 76.1% | 45.5% | 28.6% | 89.2 | 8.44 | | 8.53 | 5.38 | -0.1 |