| 1 | Johan Santana | 50 | 26 | 0 | 100 | 100 | 684.1 | 9.44 | 1.89 | 1.04 | .267 | 77.4% | 39.3% | 10.5% | 92.1 | 2.99 | | 3.21 | 3.19 | 17.8 |
| 2 | Scott Baker | 63 | 48 | 0 | 163 | 159 | 958.0 | 7.23 | 2.10 | 1.16 | .302 | 73.3% | 34.1% | 9.3% | 92.0 | 4.15 | | 3.95 | 4.08 | 15.8 |
| 3 | Francisco Liriano | 50 | 52 | 1 | 156 | 130 | 783.1 | 9.05 | 3.72 | 0.87 | .306 | 69.8% | 48.0% | 10.7% | 93.1 | 4.33 | | 3.69 | 3.62 | 13.4 |
| 4 | Joe Nathan | 23 | 11 | 216 | 387 | 0 | 391.0 | 10.86 | 2.55 | 0.71 | .250 | 82.0% | 39.5% | 7.8% | 94.3 | 2.26 | | 2.65 | 2.97 | 11.1 |
| 5 | Carl Pavano | 33 | 33 | 0 | 88 | 88 | 579.2 | 4.83 | 1.57 | 0.98 | .302 | 68.7% | 48.6% | 9.7% | 90.0 | 4.32 | | 4.02 | 4.04 | 7.6 |
| 6 | Kevin Slowey | 39 | 29 | 0 | 100 | 90 | 532.2 | 6.67 | 1.42 | 1.42 | .310 | 71.2% | 31.6% | 10.0% | 90.3 | 4.66 | | 4.24 | 4.19 | 6.7 |
| 7 | Glen Perkins | 28 | 17 | 54 | 276 | 44 | 498.0 | 6.85 | 2.37 | 1.05 | .302 | 74.0% | 42.1% | 10.0% | 94.2 | 3.89 | | 3.98 | 4.02 | 5.8 |
| 8 | Brian Duensing | 34 | 33 | 1 | 237 | 61 | 546.1 | 6.11 | 2.75 | 0.87 | .310 | 70.5% | 46.5% | 8.8% | 92.4 | 4.20 | | 3.95 | 4.13 | 5.8 |
| 9 | Carlos Silva | 33 | 37 | 0 | 96 | 91 | 570.2 | 3.63 | 1.21 | 1.31 | .301 | 70.4% | 46.7% | 12.2% | 90.4 | 4.49 | | 4.70 | 4.41 | 4.2 |
| 10 | Nick Blackburn | 43 | 55 | 0 | 145 | 137 | 818.2 | 4.27 | 2.22 | 1.29 | .311 | 69.2% | 47.7% | 12.1% | 92.4 | 4.85 | | 4.81 | 4.50 | 3.8 |
| 11 | Brad Radke | 21 | 21 | 0 | 59 | 59 | 363.0 | 4.96 | 1.36 | 1.41 | .295 | 73.3% | 41.9% | 11.9% | | 4.17 | | 4.54 | 4.32 | 3.8 |
| 12 | Boof Bonser | 18 | 25 | 0 | 96 | 60 | 391.2 | 7.28 | 2.87 | 1.40 | .314 | 67.3% | 42.9% | 12.3% | 93.6 | 5.12 | | 4.60 | 4.24 | 2.9 |
| 13 | Scott Diamond | 19 | 27 | 0 | 58 | 58 | 343.0 | 4.22 | 2.20 | 1.08 | .303 | 69.4% | 50.0% | 11.7% | 89.6 | 4.43 | | 4.46 | 4.33 | 2.8 |
| 14 | Juan Rincon | 14 | 12 | 1 | 237 | 0 | 239.0 | 8.21 | 3.69 | 0.68 | .316 | 72.0% | 47.8% | 7.8% | 93.1 | 3.69 | | 3.65 | 3.97 | 2.8 |
| 15 | Mike Pelfrey | 5 | 13 | 0 | 29 | 29 | 152.2 | 5.95 | 3.12 | 0.77 | .337 | 67.2% | 43.2% | 7.0% | 93.0 | 5.19 | | 3.99 | 4.54 | 2.4 |
| 16 | Jesse Crain | 30 | 21 | 3 | 354 | 0 | 355.0 | 6.34 | 3.27 | 0.76 | .272 | 72.4% | 45.9% | 7.6% | 95.6 | 3.52 | | 4.01 | 4.38 | 1.8 |
| 17 | Kyle Lohse | 11 | 18 | 0 | 53 | 38 | 242.1 | 4.90 | 2.56 | 1.11 | .319 | 72.1% | 42.7% | 10.1% | | 4.94 | | 4.61 | 4.71 | 1.8 |
| 18 | Jared Burton | 5 | 11 | 7 | 135 | 0 | 128.0 | 8.16 | 2.67 | 0.77 | .259 | 74.3% | 44.8% | 8.4% | 93.2 | 3.02 | | 3.50 | 3.83 | 1.8 |
| 19 | Pat Neshek | 11 | 6 | 0 | 132 | 0 | 129.2 | 10.48 | 3.12 | 1.11 | .233 | 78.9% | 31.7% | 10.3% | 77.4 | 3.05 | | 3.58 | 3.53 | 1.7 |
| 20 | Matt Garza | 8 | 13 | 0 | 26 | 24 | 133.0 | 7.11 | 3.72 | 0.95 | .342 | 70.9% | 42.7% | 8.4% | 94.2 | 4.47 | | 4.32 | 4.61 | 1.7 |
| 21 | Casey Fien | 7 | 3 | 0 | 108 | 0 | 97.0 | 9.74 | 1.95 | 1.11 | .260 | 75.1% | 32.4% | 10.5% | 92.6 | 3.25 | | 3.19 | 3.24 | 1.6 |
| 22 | Jon Rauch | 8 | 2 | 21 | 76 | 0 | 73.1 | 7.36 | 2.45 | 0.49 | .314 | 80.8% | 36.8% | 4.0% | 91.7 | 2.82 | | 3.05 | 4.03 | 1.5 |
| 23 | Kevin Correia | 9 | 13 | 0 | 31 | 31 | 185.1 | 4.90 | 2.19 | 1.17 | .313 | 76.1% | 44.0% | 11.7% | 91.3 | 4.18 | | 4.40 | 4.24 | 1.4 |
| 24 | Anthony Swarzak | 13 | 22 | 0 | 131 | 28 | 353.2 | 5.60 | 2.52 | 1.09 | .298 | 70.7% | 41.0% | 9.5% | 92.6 | 4.45 | | 4.31 | 4.46 | 1.2 |
| 25 | Dennys Reyes | 10 | 1 | 0 | 191 | 0 | 126.1 | 7.77 | 3.63 | 0.57 | .289 | 85.1% | 64.6% | 10.5% | 90.8 | 2.14 | | 3.57 | 3.54 | 1.2 |
| 26 | Samuel Deduno | 14 | 13 | 0 | 33 | 33 | 187.0 | 5.97 | 4.52 | 0.82 | .281 | 75.1% | 59.1% | 14.8% | 90.8 | 4.09 | | 4.66 | 4.34 | 1.1 |
| 27 | Andrew Albers | 2 | 5 | 0 | 10 | 10 | 60.0 | 3.75 | 1.05 | 0.90 | .278 | 60.4% | 43.5% | 7.8% | 86.7 | 4.05 | | 3.96 | 4.42 | 0.9 |
| 28 | Livan Hernandez | 10 | 8 | 0 | 23 | 23 | 139.2 | 3.48 | 1.87 | 1.16 | .345 | 66.7% | 43.7% | 9.8% | 85.0 | 5.48 | | 4.68 | 4.73 | 0.9 |
| 29 | Jose Mijares | 3 | 6 | 0 | 186 | 0 | 153.2 | 6.91 | 3.63 | 0.88 | .276 | 77.5% | 34.1% | 6.5% | 92.0 | 3.16 | | 4.13 | 4.77 | 0.7 |
| 30 | Craig Breslow | 1 | 4 | 1 | 59 | 0 | 53.0 | 7.30 | 4.25 | 0.51 | .227 | 72.2% | 37.8% | 5.0% | 90.3 | 2.89 | | 3.71 | 4.46 | 0.6 |