| 1 | Chris Sale | 30 | 24 | 8 | 118 | 59 | 477.1 | 9.37 | 2.34 | 0.91 | .287 | 78.9% | 46.3% | 11.9% | 94.2 | 3.02 | | 3.21 | 3.07 | 10.6 |
| 2 | Jake Peavy | 26 | 23 | 0 | 64 | 63 | 410.2 | 8.00 | 1.97 | 1.12 | .286 | 71.4% | 36.9% | 9.9% | 91.3 | 3.97 | | 3.66 | 3.80 | 8.1 |
| 3 | Gavin Floyd | 24 | 28 | 0 | 65 | 64 | 386.0 | 7.46 | 2.80 | 1.12 | .290 | 71.4% | 45.6% | 11.8% | 91.9 | 4.38 | | 4.14 | 3.95 | 5.1 |
| 4 | Jose Quintana | 15 | 13 | 0 | 58 | 55 | 336.1 | 6.56 | 2.62 | 0.99 | .290 | 75.7% | 44.5% | 10.3% | 91.5 | 3.61 | | 3.99 | 4.05 | 5.0 |
| 5 | Jesse Crain | 12 | 9 | 1 | 156 | 0 | 150.0 | 10.56 | 3.90 | 0.72 | .273 | 85.5% | 34.8% | 7.2% | 94.9 | 2.10 | | 3.09 | 3.53 | 3.5 |
| 6 | John Danks | 15 | 30 | 0 | 58 | 58 | 362.1 | 6.31 | 2.38 | 1.34 | .297 | 69.4% | 42.4% | 12.7% | 91.2 | 4.69 | | 4.47 | 4.10 | 3.3 |
| 7 | Mark Buehrle | 13 | 9 | 0 | 31 | 31 | 205.1 | 4.78 | 1.97 | 0.92 | .294 | 73.3% | 44.9% | 8.6% | 86.3 | 3.59 | | 3.98 | 4.14 | 3.1 |
| 8 | Nate Jones | 12 | 5 | 0 | 135 | 0 | 149.2 | 9.26 | 3.49 | 0.54 | .323 | 74.7% | 48.0% | 7.6% | 85.4 | 3.31 | | 3.00 | 3.34 | 2.9 |
| 9 | Edwin Jackson | 7 | 7 | 0 | 19 | 19 | 121.2 | 7.18 | 2.88 | 0.59 | .333 | 72.9% | 46.9% | 7.2% | 95.0 | 3.92 | | 3.25 | 3.54 | 2.8 |
| 10 | Philip Humber | 14 | 14 | 0 | 54 | 42 | 265.0 | 6.83 | 2.89 | 1.26 | .282 | 69.7% | 42.3% | 11.6% | 91.1 | 4.79 | | 4.43 | 4.24 | 2.7 |
| 11 | Matt Thornton | 6 | 18 | 6 | 176 | 0 | 152.2 | 8.08 | 2.83 | 0.65 | .309 | 67.9% | 50.3% | 8.9% | 95.9 | 3.48 | | 3.24 | 3.41 | 2.5 |
| 12 | Addison Reed | 8 | 6 | 69 | 136 | 0 | 133.2 | 9.29 | 2.83 | 0.88 | .298 | 69.6% | 32.3% | 7.8% | 94.4 | 4.17 | | 3.30 | 3.79 | 2.5 |
| 13 | Sergio Santos | 4 | 5 | 30 | 63 | 0 | 63.1 | 13.07 | 4.12 | 0.85 | .269 | 74.3% | 43.0% | 11.3% | 95.8 | 3.55 | | 2.87 | 2.69 | 1.4 |
| 14 | Hector Santiago | 8 | 10 | 4 | 78 | 27 | 224.2 | 8.73 | 4.53 | 1.08 | .275 | 80.2% | 37.5% | 10.3% | 93.0 | 3.41 | | 4.49 | 4.55 | 1.3 |
| 15 | Matt Lindstrom | 2 | 4 | 0 | 76 | 0 | 60.2 | 6.82 | 3.41 | 0.30 | .330 | 76.3% | 55.6% | 3.9% | 95.8 | 3.12 | | 3.15 | 3.87 | 0.9 |
| 16 | Donnie Veal | 2 | 3 | 1 | 74 | 0 | 42.1 | 10.20 | 4.25 | 0.64 | .269 | 70.5% | 49.0% | 9.1% | | 3.61 | | 3.13 | 3.30 | 0.6 |
| 17 | Francisco Liriano | 3 | 2 | 0 | 12 | 11 | 56.2 | 9.21 | 5.08 | 1.11 | .307 | 69.4% | 40.8% | 11.7% | 94.0 | 5.40 | | 4.51 | 4.45 | 0.5 |
| 18 | Daniel Webb | 0 | 0 | 0 | 9 | 0 | 11.1 | 7.94 | 3.18 | 0.00 | .281 | 69.2% | 56.3% | 0.0% | 96.6 | 3.18 | | 2.34 | 3.19 | 0.2 |
| 19 | Brett Myers | 3 | 4 | 0 | 35 | 0 | 34.2 | 5.45 | 2.34 | 1.04 | .252 | 78.5% | 48.1% | 13.8% | 92.1 | 3.12 | | 4.25 | 3.98 | 0.1 |
| 20 | Josh Kinney | 0 | 0 | 0 | 13 | 0 | 17.2 | 10.19 | 3.57 | 0.51 | .431 | 62.1% | 59.6% | 12.5% | 91.2 | 6.62 | | 3.03 | 2.86 | 0.1 |
| 21 | Lucas Harrell | 0 | 0 | 0 | 3 | 0 | 5.0 | 9.00 | 1.80 | 0.00 | .550 | 66.7% | 60.0% | 0.0% | 93.8 | 7.20 | | 1.63 | 3.13 | 0.1 |
| 22 | Jake Petricka | 1 | 1 | 0 | 16 | 0 | 19.1 | 4.66 | 4.66 | 0.00 | .313 | 77.4% | 62.9% | 0.0% | | 3.26 | | 3.72 | 4.43 | 0.1 |
| 23 | Eric Stults | 0 | 0 | 0 | 2 | 1 | 6.2 | 5.40 | 5.40 | 0.00 | .286 | 81.8% | 57.1% | 0.0% | 89.8 | 2.70 | | 4.14 | 4.81 | 0.1 |
| 24 | Tony Pena | 1 | 1 | 0 | 17 | 0 | 20.1 | 7.52 | 4.43 | 0.89 | .338 | 62.1% | 44.8% | 7.4% | 93.4 | 6.20 | | 4.11 | 4.50 | 0.1 |
| 25 | Jeff Gray | 0 | 0 | 0 | 6 | 0 | 13.1 | 4.72 | 2.70 | 0.67 | .273 | 84.3% | 42.2% | 5.0% | 93.1 | 2.70 | | 4.08 | 4.98 | 0.0 |
| 26 | Dylan Axelrod | 7 | 13 | 0 | 48 | 30 | 198.0 | 6.00 | 3.32 | 1.50 | .324 | 71.1% | 41.4% | 12.8% | 89.0 | 5.36 | | 5.13 | 4.77 | 0.0 |
| 27 | Jhan Marinez | 0 | 0 | 0 | 2 | 0 | 2.2 | 3.37 | 6.75 | 0.00 | .250 | 100.0% | 42.9% | 0.0% | 95.3 | 0.00 | | 4.59 | 5.15 | 0.0 |
| 28 | Casper Wells | 0 | 0 | 0 | 1 | 0 | 1.0 | 9.00 | 9.00 | 0.00 | .000 | 100.0% | 0.0% | 0.0% | 91.6 | 0.00 | | 4.05 | 6.78 | 0.0 |
| 29 | DeWayne Wise | 0 | 0 | 0 | 1 | 0 | 1.0 | 0.00 | 9.00 | 0.00 | .333 | 100.0% | 33.3% | 0.0% | 75.0 | 0.00 | | 6.09 | 7.56 | 0.0 |
| 30 | Simon Castro | 0 | 1 | 0 | 4 | 0 | 6.2 | 8.10 | 4.05 | 1.35 | .235 | 92.1% | 23.5% | 11.1% | | 2.70 | | 5.00 | 4.89 | 0.0 |