| 1 | Jon Lester | 13 | 8 | 0 | 32 | 32 | 180.2 | 8.97 | 2.99 | 1.30 | .310 | 68.7% | 46.2% | 15.8% | 91.9 | 4.33 | 3.95 | 4.10 | 3.85 | 2.9 |
| 2 | Jake Arrieta | 14 | 10 | 0 | 30 | 30 | 168.1 | 8.71 | 2.94 | 1.23 | .279 | 72.8% | 45.1% | 14.0% | 92.4 | 3.53 | 3.98 | 4.16 | 4.11 | 2.5 |
| 3 | Kyle Hendricks | 7 | 5 | 0 | 24 | 24 | 139.2 | 7.93 | 2.58 | 1.10 | .281 | 82.5% | 50.1% | 14.8% | 86.4 | 3.03 | 3.92 | 3.88 | 3.76 | 2.5 |
| 4 | Jose Quintana | 7 | 3 | 0 | 14 | 14 | 84.1 | 10.46 | 2.24 | 0.96 | .300 | 72.4% | 47.2% | 13.8% | 92.8 | 3.74 | | 3.25 | 3.24 | 2.1 |
| 5 | Mike Montgomery | 7 | 8 | 3 | 44 | 14 | 130.2 | 6.89 | 3.79 | 0.69 | .253 | 75.0% | 57.8% | 10.6% | 92.4 | 3.38 | 3.87 | 4.07 | 4.35 | 1.3 |
| 6 | Wade Davis | 4 | 2 | 32 | 59 | 0 | 58.2 | 12.12 | 4.30 | 0.92 | .262 | 87.7% | 40.5% | 12.0% | 94.8 | 2.30 | 3.60 | 3.38 | 3.57 | 1.1 |
| 7 | Pedro Strop | 5 | 4 | 0 | 69 | 0 | 60.1 | 9.70 | 3.88 | 0.60 | .270 | 76.0% | 59.2% | 8.7% | 96.2 | 2.83 | 3.01 | 3.31 | 3.80 | 1.0 |
| 8 | Carl Edwards Jr. | 5 | 4 | 0 | 73 | 0 | 66.1 | 12.75 | 5.16 | 0.81 | .192 | 78.3% | 44.4% | 13.3% | 95.5 | 2.98 | 2.99 | 3.40 | 3.43 | 1.0 |
| 9 | Brian Duensing | 1 | 1 | 0 | 68 | 0 | 62.1 | 8.81 | 2.60 | 0.87 | .306 | 84.8% | 48.6% | 10.3% | 92.6 | 2.74 | 3.17 | 3.41 | 3.82 | 0.8 |
| 10 | Eddie Butler | 4 | 3 | 0 | 13 | 11 | 54.2 | 4.94 | 4.61 | 0.66 | .266 | 75.3% | 44.3% | 6.9% | 93.5 | 3.95 | 6.00 | 4.66 | 5.59 | 0.6 |
| 11 | Koji Uehara | 3 | 4 | 2 | 49 | 0 | 43.0 | 10.47 | 2.51 | 1.47 | .284 | 72.1% | 24.6% | 12.3% | 87.2 | 3.98 | 4.30 | 3.79 | 4.03 | 0.6 |
| 12 | John Lackey | 12 | 12 | 0 | 31 | 30 | 170.2 | 7.86 | 2.79 | 1.90 | .268 | 76.3% | 41.2% | 18.2% | 91.5 | 4.59 | 5.20 | 5.30 | 4.62 | 0.6 |
| 13 | Hector Rondon | 4 | 1 | 0 | 61 | 0 | 57.1 | 10.83 | 3.14 | 1.57 | .292 | 71.9% | 48.3% | 19.6% | 96.8 | 4.24 | 4.04 | 4.12 | 3.43 | 0.3 |
| 14 | Brett Anderson | 2 | 2 | 0 | 6 | 6 | 22.0 | 6.55 | 4.91 | 0.82 | .395 | 55.6% | 50.0% | 14.3% | 91.1 | 8.18 | | 4.52 | 4.47 | 0.2 |
| 15 | Justin Wilson | 1 | 0 | 0 | 23 | 0 | 17.2 | 12.74 | 9.68 | 0.00 | .391 | 71.1% | 35.6% | 0.0% | 95.9 | 5.09 | | 3.72 | 5.33 | 0.2 |
| 16 | Dillon Maples | 0 | 0 | 0 | 6 | 0 | 5.1 | 18.56 | 10.13 | 0.00 | .600 | 50.0% | 50.0% | 0.0% | 96.9 | 10.13 | 4.64 | 2.41 | 2.74 | 0.1 |
| 17 | Pierce Johnson | 0 | 0 | 0 | 1 | 0 | 1.0 | 18.00 | 9.00 | 0.00 | .500 | 33.3% | 50.0% | 0.0% | 93.1 | 0.00 | 3.45 | 2.16 | 3.94 | 0.0 |
| 18 | Jon Jay | 0 | 0 | 0 | 1 | 0 | 1.0 | 0.00 | 0.00 | 0.00 | .250 | 100.0% | 0.0% | 0.0% | 57.3 | 0.00 | 3.37 | 3.16 | 6.72 | 0.0 |
| 19 | Zac Rosscup | 0 | 0 | 0 | 1 | 0 | 0.2 | 0.00 | 0.00 | 0.00 | .000 | 100.0% | 50.0% | 0.0% | 93.8 | 0.00 | | 3.16 | 5.83 | 0.0 |
| 20 | Miguel Montero | 0 | 0 | 0 | 1 | 0 | 1.0 | 0.00 | 18.00 | 0.00 | .000 | 100.0% | 33.3% | 0.0% | 80.5 | 0.00 | 13.61 | 9.16 | 10.94 | 0.0 |
| 21 | Jen-Ho Tseng | 1 | 0 | 0 | 2 | 1 | 6.0 | 12.00 | 3.00 | 3.00 | .231 | 57.7% | 33.3% | 28.6% | 92.1 | 7.50 | 6.78 | 6.32 | 4.07 | 0.0 |
| 22 | Rob Zastryzny | 0 | 0 | 0 | 4 | 0 | 13.0 | 7.62 | 4.85 | 1.38 | .415 | 57.9% | 50.0% | 16.7% | 90.4 | 8.31 | 5.55 | 5.31 | 4.95 | 0.0 |
| 23 | Leonys Martin | 0 | 0 | 0 | 1 | 0 | 0.2 | 0.00 | 0.00 | 13.50 | .500 | 62.5% | 40.0% | 50.0% | 89.8 | 27.00 | 39.07 | 22.66 | 8.49 | -0.1 |
| 24 | Dylan Floro | 0 | 0 | 0 | 3 | 0 | 9.2 | 5.59 | 1.86 | 1.86 | .382 | 72.4% | 50.0% | 18.2% | 92.1 | 6.52 | 5.20 | 5.54 | 4.87 | -0.1 |
| 25 | Jack Leathersich | 0 | 0 | 0 | 1 | 0 | 0.2 | 13.50 | 54.00 | 0.00 | .500 | 60.0% | 0.0% | 0.0% | 92.5 | 27.00 | | 18.16 | 20.83 | -0.1 |
| 26 | Seth Frankoff | 0 | 1 | 0 | 1 | 0 | 2.0 | 9.00 | 0.00 | 4.50 | .500 | 76.9% | 42.9% | 33.3% | 91.9 | 9.00 | 3.10 | 7.66 | 3.83 | -0.1 |
| 27 | Felix Pena | 1 | 0 | 0 | 25 | 0 | 34.1 | 9.70 | 4.72 | 2.10 | .300 | 77.6% | 34.7% | 16.0% | 94.6 | 5.24 | 4.99 | 5.78 | 5.34 | -0.2 |
| 28 | Justin Grimm | 1 | 2 | 1 | 50 | 0 | 55.1 | 9.60 | 4.39 | 1.95 | .263 | 70.4% | 43.1% | 22.2% | 95.4 | 5.53 | 5.55 | 5.36 | 4.28 | -0.4 |