| 1 | Eduardo Rodriguez | 19 | 6 | 0 | 34 | 34 | 203.1 | 9.43 | 3.32 | 1.06 | .317 | 77.6% | 48.5% | 13.3% | 93.1 | 3.81 | 3.75 | 3.86 | 4.10 | 3.7 |
| 2 | Chris Sale | 6 | 11 | 0 | 25 | 25 | 147.1 | 13.32 | 2.26 | 1.47 | .309 | 66.7% | 42.8% | 19.5% | 93.5 | 4.40 | 3.51 | 3.39 | 2.93 | 3.6 |
| 3 | David Price | 7 | 5 | 0 | 22 | 22 | 107.1 | 10.73 | 2.68 | 1.26 | .336 | 70.7% | 41.0% | 14.4% | 92.1 | 4.28 | 4.29 | 3.62 | 3.73 | 2.3 |
| 4 | Brandon Workman | 10 | 1 | 16 | 73 | 0 | 71.2 | 13.06 | 5.65 | 0.13 | .209 | 77.7% | 51.1% | 2.6% | 93.1 | 1.88 | 2.86 | 2.46 | 3.33 | 2.1 |
| 5 | Rick Porcello | 14 | 12 | 0 | 32 | 32 | 174.1 | 7.38 | 2.32 | 1.60 | .308 | 65.7% | 38.1% | 13.1% | 91.1 | 5.52 | 4.89 | 4.76 | 5.14 | 1.8 |
| 6 | Matt Barnes | 5 | 4 | 4 | 70 | 0 | 64.1 | 15.39 | 5.32 | 1.12 | .339 | 77.7% | 47.0% | 19.5% | 96.8 | 3.78 | 3.14 | 3.28 | 2.93 | 1.3 |
| 7 | Marcus Walden | 9 | 2 | 2 | 70 | 0 | 78.0 | 8.77 | 3.69 | 0.69 | .264 | 67.0% | 53.5% | 10.3% | 94.4 | 3.81 | 3.89 | 3.69 | 4.17 | 1.0 |
| 8 | Josh Taylor | 2 | 2 | 0 | 52 | 1 | 47.1 | 11.79 | 3.04 | 0.95 | .321 | 80.4% | 44.2% | 12.8% | 94.9 | 3.04 | 3.31 | 3.11 | 3.37 | 0.9 |
| 9 | Darwinzon Hernandez | 0 | 1 | 0 | 29 | 1 | 30.1 | 16.91 | 7.71 | 0.30 | .433 | 69.6% | 45.0% | 5.3% | 95.6 | 4.45 | 3.11 | 2.75 | 3.57 | 0.6 |
| 10 | Ryan Weber | 2 | 4 | 0 | 18 | 3 | 40.2 | 6.42 | 1.77 | 1.11 | .316 | 65.4% | 48.6% | 12.5% | 88.4 | 5.09 | 4.20 | 4.20 | 4.56 | 0.3 |
| 11 | Ryan Brasier | 2 | 4 | 7 | 62 | 0 | 55.2 | 9.86 | 3.40 | 1.46 | .286 | 67.3% | 31.8% | 12.5% | 96.2 | 4.85 | 5.02 | 4.42 | 4.89 | 0.3 |
| 12 | Travis Lakins Sr. | 0 | 1 | 0 | 16 | 3 | 23.1 | 6.94 | 3.86 | 0.39 | .306 | 70.6% | 47.2% | 4.0% | 93.8 | 3.86 | 4.69 | 3.64 | 5.22 | 0.3 |
| 13 | Hector Velazquez | 1 | 4 | 0 | 34 | 8 | 56.1 | 7.83 | 4.47 | 1.12 | .321 | 61.9% | 38.6% | 10.6% | 92.3 | 5.43 | 5.26 | 4.74 | 5.46 | 0.2 |
| 14 | Heath Hembree | 1 | 0 | 2 | 45 | 0 | 39.2 | 10.44 | 4.08 | 1.59 | .273 | 77.4% | 21.7% | 10.9% | 93.7 | 3.86 | 4.38 | 4.78 | 5.69 | 0.1 |
| 15 | Bobby Poyner | 0 | 1 | 0 | 13 | 1 | 11.2 | 8.49 | 3.86 | 1.54 | .267 | 53.0% | 28.1% | 11.8% | 89.4 | 6.94 | 6.28 | 5.10 | 5.77 | 0.0 |
| 16 | Brian Johnson | 1 | 3 | 0 | 21 | 7 | 40.1 | 6.92 | 5.13 | 1.34 | .353 | 69.5% | 41.9% | 10.7% | 88.9 | 6.02 | 5.19 | 5.32 | 6.15 | 0.0 |
| 17 | Colten Brewer | 1 | 2 | 0 | 58 | 0 | 54.2 | 8.56 | 5.60 | 0.99 | .333 | 79.7% | 50.3% | 14.0% | 96.0 | 4.12 | 4.63 | 4.71 | 4.85 | 0.0 |
| 18 | Andrew Cashner | 2 | 5 | 1 | 25 | 6 | 53.2 | 7.04 | 4.86 | 1.34 | .325 | 64.7% | 47.2% | 14.8% | 94.6 | 6.20 | | 5.38 | 5.44 | -0.1 |
| 19 | Tyler Thornburg | 0 | 0 | 0 | 16 | 0 | 18.2 | 10.61 | 4.82 | 1.93 | .347 | 60.6% | 30.2% | 15.4% | 93.8 | 7.71 | 6.66 | 5.41 | 5.40 | -0.1 |
| 20 | Eduardo Nunez | 0 | 0 | 0 | 1 | 0 | 1.0 | 0.00 | 0.00 | 9.00 | .000 | 100.0% | 25.0% | 33.3% | 82.0 | 9.00 | 9.55 | 16.21 | 9.18 | -0.1 |
| 21 | Erasmo Ramirez | 0 | 0 | 0 | 1 | 0 | 3.0 | 3.00 | 3.00 | 6.00 | .200 | 62.5% | 45.5% | 50.0% | 91.6 | 12.00 | 17.87 | 13.21 | 7.20 | -0.1 |
| 22 | Jhoulys Chacin | 0 | 2 | 0 | 6 | 5 | 14.2 | 12.89 | 4.30 | 3.68 | .303 | 75.3% | 38.5% | 40.0% | 90.7 | 7.36 | | 7.10 | 3.82 | -0.2 |
| 23 | Trevor Kelley | 0 | 3 | 0 | 10 | 0 | 8.1 | 6.48 | 5.40 | 2.16 | .259 | 53.6% | 17.2% | 10.5% | | 8.64 | 9.21 | 6.69 | 8.11 | -0.2 |
| 24 | Michael Shawaryn | 0 | 0 | 0 | 14 | 0 | 20.1 | 12.84 | 5.75 | 2.21 | .412 | 59.5% | 33.9% | 17.9% | 91.9 | 9.74 | 5.93 | 6.21 | 5.76 | -0.2 |
| 25 | Nathan Eovaldi | 2 | 1 | 0 | 23 | 12 | 67.2 | 9.31 | 4.66 | 2.13 | .315 | 73.1% | 44.6% | 22.9% | 97.6 | 5.99 | 5.06 | 5.90 | 4.89 | -0.3 |
| 26 | Steven Wright | 0 | 1 | 0 | 6 | 0 | 6.1 | 7.11 | 5.68 | 4.26 | .400 | 84.7% | 34.8% | 37.5% | 82.9 | 8.53 | 9.21 | 10.16 | 6.52 | -0.3 |
| 27 | Josh A. Smith | 0 | 3 | 1 | 18 | 2 | 31.0 | 8.42 | 2.32 | 2.90 | .292 | 75.8% | 34.7% | 25.6% | 91.5 | 5.81 | 5.85 | 6.60 | 4.91 | -0.4 |