| 1 | Mariano Rivera | NYY | 8.22 | 2.01 | 4.10 | 0.50 | 23.0% | 5.6% | 17.4% | .209 | 1.00 | .263 | 80.4% | 49 | 62 | 69 | 2.21 | 2.76 | -0.56 | 3.00 | 2.60 |
| 2 | Willie Foster | - - - | 5.53 | 2.86 | 1.93 | 0.28 | 14.3% | 8.0% | 6.3% | .229 | 1.17 | .256 | 133.1% | 61 | 90 | | 2.63 | 3.43 | -0.85 | | |
| 3 | Clayton Kershaw | LAD | 9.81 | 2.44 | 4.02 | 0.54 | 27.7% | 6.9% | 20.8% | .202 | 1.01 | .271 | 78.4% | 62 | 65 | 74 | 2.37 | 2.55 | -0.18 | 2.92 | 2.99 |
| 4 | Bullet Rogan | - - - | 5.51 | 2.43 | 2.27 | 0.17 | 14.5% | 6.7% | 7.8% | .232 | 1.16 | .272 | 82.4% | 63 | 81 | | 2.65 | 3.05 | -0.41 | | |
| 5 | Satchel Paige | - - - | 7.70 | 2.36 | 3.27 | 0.32 | 20.4% | 7.1% | 13.3% | .223 | 1.10 | .272 | 95.4% | 66 | 71 | | 2.70 | 2.48 | 0.13 | | |
| 6 | Pedro Martinez | - - - | 10.04 | 2.42 | 4.15 | 0.76 | 27.7% | 6.7% | 21.0% | .212 | 1.05 | .279 | 75.9% | 66 | 68 | 79 | 2.93 | 2.91 | 0.01 | 3.45 | 3.26 |
| 7 | Walter Johnson | WAS | 5.34 | 2.07 | 2.57 | 0.15 | 12.6% | 6.4% | 6.3% | .225 | 1.06 | .264 | 72.2% | 68 | 76 | | 2.17 | 2.45 | -0.28 | | |
| 8 | Lefty Grove | - - - | 5.18 | 2.71 | 1.91 | 0.37 | 13.6% | 7.1% | 6.5% | .250 | 1.28 | .284 | 71.8% | 68 | 76 | | 3.06 | 3.43 | -0.37 | | |
| 9 | Hoyt Wilhelm | - - - | 6.43 | 3.11 | 2.07 | 0.60 | 17.6% | 8.5% | 9.1% | .211 | 1.12 | .245 | 76.4% | 68 | 81 | | 2.52 | 3.06 | -0.53 | | |
| 10 | Ed Walsh | - - - | 5.27 | 1.87 | 2.81 | 0.07 | 7.1% | 12.1% | -5.1% | .219 | 1.00 | .260 | 71.7% | 69 | 80 | | 1.82 | 2.02 | -0.20 | | |
| 11 | Ray Brown | - - - | 4.22 | 2.43 | 1.73 | 0.27 | 12.0% | 6.7% | 5.3% | .243 | 1.21 | .266 | 99.8% | 69 | 89 | | 3.06 | 3.30 | -0.14 | | |
| 12 | Dan Quisenberry | - - - | 3.27 | 1.40 | 2.34 | 0.51 | 8.9% | 3.8% | 5.1% | .261 | 1.18 | .276 | 76.1% | 70 | 82 | | 2.77 | 3.24 | -0.47 | | |
| 13 | Addie Joss | CLE | 3.56 | 1.41 | 2.53 | 0.07 | | | | .223 | 0.97 | .249 | 69.3% | 70 | 87 | | 1.89 | 2.25 | -0.36 | | |
| 14 | Joe Wood | - - - | 6.20 | 2.64 | 2.35 | 0.06 | 3.9% | 11.8% | -7.9% | .220 | 1.09 | .270 | 69.7% | 70 | 78 | | 2.03 | 2.26 | -0.23 | | |
| 15 | Al Spalding | - - - | 0.44 | 0.49 | 0.91 | 0.05 | | | | .286 | 1.19 | .289 | 48.0% | 70 | 96 | | 2.14 | 2.93 | -0.80 | | |
| 16 | Roger Clemens | - - - | 8.55 | 2.89 | 2.96 | 0.66 | 23.1% | 7.8% | 15.3% | .226 | 1.17 | .284 | 74.6% | 70 | 71 | 80 | 3.12 | 3.09 | 0.04 | 3.51 | 3.59 |
| 17 | Mordecai Brown | - - - | 3.90 | 1.91 | 2.04 | 0.12 | 10.3% | 4.4% | 5.9% | .232 | 1.07 | .260 | 70.9% | 71 | 83 | | 2.06 | 2.42 | -0.36 | | |
| 18 | Trevor Hoffman | - - - | 9.36 | 2.54 | 3.69 | 0.83 | 25.8% | 7.0% | 18.8% | .208 | 1.06 | .263 | 76.7% | 71 | 73 | 88 | 2.87 | 3.08 | -0.22 | 3.79 | 3.30 |
| 19 | Brandon Webb | ARI | 7.26 | 2.97 | 2.45 | 0.63 | 19.3% | 7.9% | 11.4% | .239 | 1.24 | .286 | 72.5% | 72 | 77 | 75 | 3.27 | 3.50 | -0.24 | 3.30 | 3.34 |
| 20 | Pete Alexander | - - - | 3.81 | 1.65 | 2.31 | 0.28 | 8.3% | 3.6% | 4.7% | .246 | 1.12 | .270 | 71.4% | 73 | 81 | | 2.56 | 2.92 | -0.36 | | |
| 21 | John Franco | - - - | 7.04 | 3.58 | 1.97 | 0.59 | 18.4% | 9.3% | 9.0% | .243 | 1.33 | .290 | 77.5% | 73 | 86 | 99 | 2.89 | 3.45 | -0.56 | 4.31 | 4.16 |
| 22 | Spud Chandler | NYY | 3.72 | 2.81 | 1.33 | 0.39 | 10.1% | 7.6% | 2.5% | .236 | 1.21 | .256 | 73.3% | 73 | 88 | | 2.84 | 3.43 | -0.60 | | |
| 23 | Kid Nichols | - - - | 3.32 | 2.26 | 1.47 | 0.28 | | | | .256 | 1.22 | .277 | 62.9% | 73 | 86 | | 2.95 | 3.55 | -0.59 | | |
| 24 | Chris Sale | CHW | 10.09 | 2.11 | 4.78 | 0.92 | 27.9% | 5.8% | 22.0% | .223 | 1.06 | .291 | 77.9% | 74 | 74 | 75 | 3.00 | 3.06 | -0.06 | 3.04 | 2.93 |
| 25 | Cy Young | - - - | 3.43 | 1.49 | 2.30 | 0.17 | | | | .255 | 1.13 | .279 | 64.1% | 74 | 80 | | 2.63 | 2.89 | -0.26 | | |
| 26 | Johan Santana | - - - | 8.83 | 2.52 | 3.51 | 0.98 | 24.1% | 6.9% | 17.2% | .225 | 1.13 | .276 | 77.0% | 74 | 81 | 81 | 3.20 | 3.44 | -0.23 | 3.50 | 3.36 |
| 27 | William Bell | - - - | 3.91 | 1.98 | 1.98 | 0.22 | 9.8% | 5.5% | 4.3% | .249 | 1.18 | .281 | 98.2% | 74 | 88 | | 3.26 | 3.33 | -0.13 | | |
| 28 | Christy Mathewson | - - - | 4.71 | 1.59 | 2.96 | 0.17 | 6.4% | 2.7% | 3.7% | .238 | 1.06 | .273 | 70.2% | 74 | 76 | | 2.13 | 2.27 | -0.13 | | |
| 29 | Noodles Hahn | - - - | 4.07 | 1.69 | 2.41 | 0.12 | | | | .251 | 1.13 | .282 | 66.1% | 75 | 77 | | 2.55 | 2.65 | -0.11 | | |
| 30 | Jim Devlin | - - - | 1.75 | 0.57 | 3.07 | 0.04 | | | | .266 | 1.09 | .279 | 49.5% | 75 | 86 | | 2.05 | 2.36 | -0.31 | | |