| 1 | Anibal Sanchez | DET | 22 | 13 | 0 | 51 | 50 | 308.0 | 8.88 | 2.45 | 0.38 | .294 | 72.3% | 45.5% | 4.6% | 93.5 | 2.92 | | 2.52 | 3.18 | 9.2 |
| 2 | Clayton Kershaw | LAD | 37 | 12 | 0 | 60 | 60 | 434.1 | 9.76 | 1.72 | 0.41 | .263 | 81.0% | 48.6% | 6.1% | 93.5 | 1.80 | | 2.12 | 2.51 | 15.1 |
| 3 | Adam Wainwright | STL | 39 | 18 | 0 | 66 | 66 | 468.2 | 7.64 | 1.63 | 0.48 | .287 | 76.2% | 47.8% | 6.6% | 91.5 | 2.67 | | 2.71 | 3.06 | 11.1 |
| 4 | Garrett Richards | LAA | 20 | 12 | 1 | 73 | 43 | 313.2 | 7.60 | 2.73 | 0.49 | .283 | 71.7% | 54.4% | 7.3% | 96.2 | 3.33 | | 3.09 | 3.35 | 6.0 |
| 5 | Tyson Ross | SDP | 16 | 22 | 0 | 66 | 47 | 320.2 | 8.81 | 3.26 | 0.59 | .288 | 73.7% | 56.2% | 9.9% | 94.9 | 2.95 | | 3.23 | 3.23 | 4.6 |
| 6 | Lance Lynn | STL | 30 | 20 | 0 | 66 | 66 | 405.1 | 8.42 | 3.29 | 0.60 | .302 | 74.9% | 43.7% | 6.7% | 93.5 | 3.35 | | 3.31 | 3.74 | 6.9 |
| 7 | Hyun-Jin Ryu | LAD | 28 | 15 | 0 | 56 | 56 | 344.0 | 7.67 | 2.04 | 0.60 | .306 | 75.3% | 49.2% | 7.5% | 91.2 | 3.17 | | 2.97 | 3.27 | 7.8 |
| 8 | Francisco Liriano | PIT | 23 | 18 | 0 | 55 | 55 | 323.1 | 9.41 | 4.01 | 0.61 | .285 | 76.1% | 52.4% | 10.0% | 93.6 | 3.20 | | 3.26 | 3.26 | 4.7 |
| 9 | Nathan Eovaldi | MIA | 10 | 20 | 0 | 51 | 51 | 306.0 | 6.47 | 2.44 | 0.62 | .310 | 68.4% | 44.5% | 6.5% | 96.8 | 4.03 | | 3.45 | 3.91 | 4.8 |
| 10 | Felix Hernandez | SEA | 27 | 16 | 0 | 65 | 65 | 440.1 | 9.48 | 1.88 | 0.63 | .284 | 76.0% | 53.9% | 10.0% | 93.1 | 2.55 | | 2.58 | 2.58 | 11.7 |
| 11 | Mat Latos | CIN | 19 | 12 | 0 | 48 | 48 | 313.0 | 7.50 | 2.42 | 0.66 | .289 | 74.0% | 42.6% | 7.0% | 92.9 | 3.19 | | 3.28 | 3.70 | 6.8 |
| 12 | Corey Kluber | CLE | 29 | 14 | 0 | 60 | 58 | 383.0 | 9.52 | 1.97 | 0.68 | .321 | 76.3% | 47.0% | 9.4% | 94.0 | 2.98 | | 2.71 | 2.77 | 10.1 |
| 13 | Gio Gonzalez | WSN | 21 | 18 | 0 | 59 | 59 | 354.1 | 8.99 | 3.35 | 0.69 | .289 | 73.3% | 44.3% | 8.2% | 93.3 | 3.45 | | 3.24 | 3.46 | 6.5 |
| 14 | A.J. Burnett | - - - | 18 | 29 | 0 | 64 | 64 | 404.2 | 8.87 | 3.63 | 0.69 | .303 | 69.4% | 53.4% | 10.4% | 93.1 | 3.98 | | 3.51 | 3.46 | 5.7 |
| 15 | Jordan Zimmermann | WSN | 33 | 14 | 0 | 64 | 64 | 413.0 | 7.47 | 1.50 | 0.70 | .286 | 75.1% | 44.1% | 7.9% | 94.5 | 2.96 | | 3.03 | 3.30 | 9.2 |
| 16 | Alex Cobb | TBR | 21 | 12 | 0 | 49 | 49 | 309.2 | 8.22 | 2.67 | 0.70 | .281 | 79.5% | 56.0% | 11.1% | 92.2 | 2.82 | | 3.29 | 3.19 | 4.8 |
| 17 | Justin Masterson | - - - | 21 | 19 | 0 | 60 | 54 | 321.2 | 8.70 | 4.06 | 0.70 | .308 | 70.4% | 58.1% | 12.3% | 92.5 | 4.42 | | 3.81 | 3.63 | 4.3 |
| 18 | Tim Hudson | - - - | 17 | 20 | 0 | 52 | 52 | 320.2 | 6.03 | 1.96 | 0.70 | .293 | 69.4% | 54.2% | 9.4% | 90.3 | 3.73 | | 3.51 | 3.56 | 3.3 |
| 19 | Jon Lester | - - - | 31 | 19 | 0 | 65 | 65 | 433.0 | 8.25 | 2.39 | 0.73 | .299 | 74.8% | 43.7% | 7.8% | 93.3 | 3.10 | | 3.19 | 3.49 | 8.7 |
| 20 | Jon Niese | NYM | 17 | 19 | 0 | 54 | 54 | 330.2 | 6.61 | 2.53 | 0.73 | .314 | 73.6% | 49.4% | 9.2% | 90.5 | 3.54 | | 3.63 | 3.72 | 4.6 |
| 21 | Cole Hamels | PHI | 17 | 23 | 0 | 63 | 63 | 424.2 | 8.48 | 2.31 | 0.74 | .295 | 77.1% | 44.5% | 8.8% | 92.8 | 3.05 | | 3.17 | 3.33 | 9.1 |
| 22 | Jose Quintana | CHW | 18 | 18 | 0 | 65 | 65 | 400.1 | 7.69 | 2.43 | 0.74 | .300 | 72.7% | 43.6% | 7.8% | 92.1 | 3.42 | | 3.31 | 3.62 | 8.3 |
| 23 | C.J. Wilson | LAA | 30 | 17 | 0 | 64 | 64 | 388.0 | 7.86 | 3.94 | 0.74 | .303 | 72.1% | 45.9% | 8.9% | 91.6 | 3.90 | | 3.87 | 4.01 | 3.4 |
| 24 | Max Scherzer | DET | 39 | 8 | 0 | 65 | 65 | 434.2 | 10.19 | 2.46 | 0.75 | .288 | 75.9% | 36.5% | 7.6% | 93.9 | 3.02 | | 2.79 | 3.14 | 11.5 |
| 25 | Chris Archer | TBR | 19 | 16 | 0 | 55 | 55 | 323.1 | 7.63 | 3.06 | 0.75 | .279 | 74.2% | 46.6% | 8.9% | 95.6 | 3.28 | | 3.66 | 3.78 | 4.0 |
| 26 | Zack Greinke | LAD | 32 | 12 | 0 | 60 | 60 | 380.0 | 8.41 | 2.11 | 0.76 | .294 | 80.2% | 47.2% | 10.3% | 92.4 | 2.68 | | 3.09 | 3.06 | 7.9 |
| 27 | Doug Fister | - - - | 30 | 15 | 0 | 58 | 57 | 372.2 | 6.21 | 1.64 | 0.77 | .301 | 77.1% | 51.9% | 9.5% | 89.1 | 3.12 | | 3.55 | 3.61 | 5.6 |
| 28 | Madison Bumgarner | SFG | 31 | 19 | 0 | 64 | 64 | 418.2 | 8.99 | 2.26 | 0.77 | .275 | 75.8% | 45.5% | 9.2% | 92.6 | 2.88 | | 3.05 | 3.15 | 7.2 |
| 29 | Justin Verlander | DET | 28 | 24 | 0 | 66 | 66 | 424.1 | 7.97 | 2.97 | 0.78 | .317 | 70.7% | 39.0% | 7.3% | 93.7 | 3.99 | | 3.50 | 3.92 | 8.0 |
| 30 | Dallas Keuchel | HOU | 18 | 19 | 0 | 60 | 51 | 353.2 | 6.85 | 2.54 | 0.79 | .315 | 71.9% | 60.0% | 13.5% | 90.1 | 3.89 | | 3.66 | 3.37 | 4.5 |