| 1 | Lance Lynn | STL | 11 | 8 | 0 | 33 | 33 | 186.1 | 7.39 | 3.77 | 1.30 | .244 | 79.0% | 44.0% | 14.2% | 92.5 | 3.43 | 4.27 | 4.82 | 4.75 | 1.2 |
| 2 | Ervin Santana | MIN | 16 | 8 | 0 | 33 | 33 | 211.1 | 7.11 | 2.60 | 1.32 | .245 | 79.5% | 41.2% | 11.8% | 93.2 | 3.28 | 3.84 | 4.46 | 4.77 | 2.7 |
| 3 | Max Scherzer | WSN | 16 | 6 | 0 | 31 | 31 | 200.2 | 12.02 | 2.47 | 0.99 | .245 | 80.6% | 36.5% | 10.8% | 94.3 | 2.51 | 2.51 | 2.90 | 3.28 | 6.4 |
| 4 | Jeremy Hellickson | - - - | 8 | 11 | 0 | 30 | 30 | 164.0 | 5.27 | 2.58 | 1.92 | .246 | 66.3% | 34.9% | 15.1% | 90.2 | 5.43 | 5.44 | 5.77 | 5.51 | 0.3 |
| 5 | Jose Urena | MIA | 14 | 7 | 0 | 34 | 28 | 169.2 | 5.99 | 3.39 | 1.38 | .249 | 79.0% | 43.1% | 13.1% | 95.8 | 3.82 | 5.23 | 5.20 | 5.29 | 0.2 |
| 6 | Gio Gonzalez | WSN | 15 | 9 | 0 | 32 | 32 | 201.0 | 8.42 | 3.54 | 0.94 | .258 | 81.5% | 45.8% | 11.1% | 90.4 | 2.96 | 3.71 | 3.93 | 4.24 | 3.8 |
| 7 | Andrew Cashner | TEX | 11 | 11 | 0 | 28 | 28 | 166.2 | 4.64 | 3.46 | 0.81 | .266 | 74.0% | 48.6% | 8.6% | 94.0 | 3.40 | 4.73 | 4.61 | 5.30 | 2.2 |
| 8 | Clayton Kershaw | LAD | 18 | 4 | 0 | 27 | 27 | 175.0 | 10.39 | 1.54 | 1.18 | .267 | 87.4% | 47.9% | 15.9% | 92.9 | 2.31 | 2.92 | 3.07 | 2.84 | 4.3 |
| 9 | Corey Kluber | CLE | 18 | 4 | 0 | 29 | 29 | 203.2 | 11.71 | 1.59 | 0.93 | .267 | 82.6% | 44.5% | 13.5% | 92.8 | 2.25 | 2.59 | 2.50 | 2.52 | 7.2 |
| 10 | Robbie Ray | ARI | 15 | 5 | 0 | 28 | 28 | 162.0 | 12.11 | 3.94 | 1.28 | .267 | 84.5% | 40.3% | 15.6% | 94.3 | 2.89 | 3.76 | 3.72 | 3.49 | 3.3 |
| 11 | John Lackey | CHC | 12 | 12 | 0 | 31 | 30 | 170.2 | 7.86 | 2.79 | 1.90 | .268 | 76.3% | 41.2% | 18.2% | 91.5 | 4.59 | 5.20 | 5.30 | 4.62 | 0.6 |
| 12 | Sonny Gray | - - - | 10 | 12 | 0 | 27 | 27 | 162.1 | 8.48 | 3.16 | 1.05 | .269 | 69.6% | 52.8% | 15.1% | 93.7 | 3.55 | 4.12 | 3.90 | 3.76 | 2.7 |
| 13 | Justin Verlander | - - - | 15 | 8 | 0 | 33 | 33 | 206.0 | 9.57 | 3.15 | 1.18 | .271 | 79.7% | 33.5% | 11.5% | 95.3 | 3.36 | 4.27 | 3.84 | 4.17 | 4.1 |
| 14 | Luis Severino | NYY | 14 | 6 | 0 | 31 | 31 | 193.1 | 10.71 | 2.37 | 0.98 | .272 | 75.5% | 50.6% | 14.0% | 97.6 | 2.98 | 3.10 | 3.07 | 3.04 | 5.6 |
| 15 | Jhoulys Chacin | SDP | 13 | 10 | 0 | 32 | 32 | 180.1 | 7.64 | 3.59 | 0.95 | .272 | 74.4% | 49.1% | 11.4% | 91.8 | 3.89 | 4.04 | 4.26 | 4.54 | 2.3 |
| 16 | Dylan Bundy | BAL | 13 | 9 | 0 | 28 | 28 | 169.2 | 8.06 | 2.71 | 1.38 | .273 | 73.7% | 32.8% | 11.5% | 92.2 | 4.24 | 4.45 | 4.38 | 4.77 | 2.8 |
| 17 | Michael Fulmer | DET | 10 | 12 | 0 | 25 | 25 | 164.2 | 6.23 | 2.19 | 0.71 | .273 | 65.6% | 49.2% | 8.8% | 95.8 | 3.83 | 4.12 | 3.67 | 4.24 | 3.6 |
| 18 | Stephen Strasburg | WSN | 15 | 4 | 0 | 28 | 28 | 175.1 | 10.47 | 2.41 | 0.67 | .274 | 77.9% | 46.8% | 8.7% | 95.9 | 2.52 | 2.92 | 2.72 | 3.27 | 5.9 |
| 19 | Jake Arrieta | CHC | 14 | 10 | 0 | 30 | 30 | 168.1 | 8.71 | 2.94 | 1.23 | .279 | 72.8% | 45.1% | 14.0% | 92.4 | 3.53 | 3.98 | 4.16 | 4.11 | 2.5 |
| 20 | Julio Teheran | ATL | 11 | 13 | 0 | 32 | 32 | 188.1 | 7.22 | 3.44 | 1.48 | .281 | 73.1% | 40.0% | 13.7% | 91.8 | 4.49 | 4.57 | 4.95 | 4.96 | 1.0 |
| 21 | Alex Cobb | TBR | 12 | 10 | 0 | 29 | 29 | 179.1 | 6.42 | 2.21 | 1.10 | .282 | 75.7% | 47.8% | 13.0% | 91.7 | 3.66 | 4.54 | 4.16 | 4.24 | 2.2 |
| 22 | Yu Darvish | - - - | 10 | 12 | 0 | 31 | 31 | 186.2 | 10.08 | 2.80 | 1.30 | .283 | 75.6% | 40.7% | 15.1% | 94.5 | 3.86 | 3.71 | 3.83 | 3.65 | 3.7 |
| 23 | Carlos Martinez | STL | 12 | 11 | 0 | 32 | 32 | 205.0 | 9.53 | 3.12 | 1.19 | .284 | 74.9% | 51.3% | 16.4% | 96.6 | 3.64 | 3.42 | 3.91 | 3.63 | 3.2 |
| 24 | Zack Greinke | ARI | 17 | 7 | 0 | 32 | 32 | 202.1 | 9.56 | 2.00 | 1.11 | .285 | 75.3% | 46.8% | 13.4% | 90.8 | 3.20 | 3.52 | 3.31 | 3.34 | 4.9 |
| 25 | Dan Straily | MIA | 10 | 9 | 0 | 33 | 33 | 181.2 | 8.42 | 2.97 | 1.54 | .288 | 76.4% | 34.2% | 13.0% | 90.7 | 4.26 | 4.01 | 4.58 | 4.70 | 2.0 |
| 26 | Jason Vargas | KCR | 18 | 11 | 0 | 32 | 32 | 179.2 | 6.71 | 2.91 | 1.35 | .289 | 77.6% | 40.3% | 12.1% | 86.4 | 4.16 | 4.57 | 4.67 | 4.94 | 1.8 |
| 27 | R.A. Dickey | ATL | 10 | 10 | 0 | 31 | 31 | 190.0 | 6.44 | 3.17 | 1.23 | .290 | 73.2% | 46.9% | 13.2% | 83.8 | 4.26 | 4.36 | 4.72 | 4.79 | 1.5 |
| 28 | Ty Blach | SFG | 8 | 12 | 0 | 34 | 24 | 163.2 | 4.01 | 2.36 | 0.93 | .290 | 66.3% | 46.7% | 9.6% | 90.3 | 4.78 | 4.93 | 4.42 | 5.01 | 1.2 |
| 29 | Marco Estrada | TOR | 10 | 9 | 0 | 33 | 33 | 186.0 | 8.52 | 3.44 | 1.50 | .295 | 71.9% | 30.3% | 11.2% | 89.9 | 4.98 | 3.98 | 4.61 | 5.09 | 2.6 |
| 30 | Gerrit Cole | PIT | 12 | 12 | 0 | 33 | 33 | 203.0 | 8.69 | 2.44 | 1.37 | .298 | 74.6% | 45.8% | 15.9% | 96.2 | 4.26 | 4.33 | 4.08 | 3.81 | 3.4 |