| 1 | Reynaldo Lopez | CHW | 10 | 15 | 0 | 33 | 33 | 184.0 | 8.27 | 3.18 | 1.71 | .316 | 69.2% | 35.0% | 14.0% | 95.5 | 5.38 | 5.13 | 5.04 | 5.27 | 2.4 |
| 2 | Julio Teheran | ATL | 10 | 11 | 0 | 33 | 33 | 174.2 | 8.35 | 4.28 | 1.13 | .266 | 76.6% | 39.0% | 11.2% | 89.8 | 3.81 | 4.76 | 4.66 | 5.26 | 1.6 |
| 3 | Mike Fiers | OAK | 15 | 4 | 0 | 33 | 33 | 184.2 | 6.14 | 2.58 | 1.46 | .254 | 78.5% | 39.9% | 13.8% | 90.5 | 3.90 | 5.06 | 4.97 | 5.19 | 1.7 |
| 4 | Sandy Alcantara | MIA | 6 | 14 | 0 | 32 | 32 | 197.1 | 6.89 | 3.69 | 1.05 | .271 | 73.8% | 44.6% | 10.8% | 95.7 | 3.88 | 4.60 | 4.55 | 5.17 | 2.3 |
| 5 | Rick Porcello | BOS | 14 | 12 | 0 | 32 | 32 | 174.1 | 7.38 | 2.32 | 1.60 | .308 | 65.7% | 38.1% | 13.1% | 91.1 | 5.52 | 4.89 | 4.76 | 5.14 | 1.8 |
| 6 | Marco Gonzales | SEA | 16 | 13 | 0 | 34 | 34 | 203.0 | 6.52 | 2.48 | 1.02 | .295 | 69.2% | 40.7% | 9.3% | 89.1 | 3.99 | 4.26 | 4.15 | 5.11 | 3.6 |
| 7 | Anibal Sanchez | WSN | 11 | 8 | 0 | 30 | 30 | 166.0 | 7.27 | 3.14 | 1.19 | .265 | 74.9% | 38.0% | 11.1% | 90.5 | 3.85 | 4.32 | 4.44 | 5.10 | 2.4 |
| 8 | Jeff Samardzija | SFG | 11 | 12 | 0 | 32 | 32 | 181.1 | 6.95 | 2.43 | 1.39 | .240 | 76.9% | 36.4% | 12.6% | 91.7 | 3.52 | 4.73 | 4.59 | 5.02 | 1.5 |
| 9 | Brad Keller | KCR | 7 | 14 | 0 | 28 | 28 | 165.1 | 6.64 | 3.81 | 0.82 | .282 | 72.2% | 50.0% | 10.2% | 93.8 | 4.19 | 4.82 | 4.35 | 4.94 | 2.2 |
| 10 | Ivan Nova | CHW | 11 | 12 | 0 | 34 | 34 | 187.0 | 5.49 | 2.26 | 1.44 | .322 | 72.8% | 46.1% | 15.8% | 92.6 | 4.72 | 5.63 | 4.98 | 4.91 | 2.1 |
| 11 | Brett Anderson | OAK | 13 | 9 | 0 | 31 | 31 | 176.0 | 4.60 | 2.51 | 1.02 | .278 | 74.8% | 54.5% | 13.3% | 91.2 | 3.89 | 5.44 | 4.57 | 4.79 | 2.0 |
| 12 | Mike Leake | - - - | 12 | 11 | 0 | 32 | 32 | 197.0 | 5.80 | 1.23 | 1.87 | .295 | 72.6% | 46.8% | 18.2% | 88.8 | 4.29 | 5.74 | 5.19 | 4.76 | 0.9 |
| 13 | Zach Eflin | PHI | 10 | 13 | 0 | 32 | 28 | 163.1 | 7.11 | 2.64 | 1.54 | .291 | 73.9% | 44.4% | 16.0% | 94.0 | 4.13 | 4.14 | 4.85 | 4.76 | 1.5 |
| 14 | Martin Perez | MIN | 10 | 7 | 0 | 32 | 29 | 165.1 | 7.35 | 3.65 | 1.25 | .316 | 67.6% | 48.0% | 15.0% | 94.2 | 5.12 | 4.11 | 4.66 | 4.69 | 1.9 |
| 15 | Tanner Roark | - - - | 10 | 10 | 0 | 31 | 31 | 165.1 | 8.60 | 2.78 | 1.52 | .322 | 78.1% | 36.2% | 15.5% | 92.1 | 4.35 | 5.26 | 4.67 | 4.64 | 2.0 |
| 16 | Jakob Junis | KCR | 9 | 14 | 0 | 31 | 31 | 175.1 | 8.42 | 2.98 | 1.59 | .318 | 70.3% | 42.4% | 16.7% | 91.8 | 5.24 | 5.41 | 4.82 | 4.63 | 1.5 |
| 17 | Mike Minor | TEX | 14 | 10 | 0 | 32 | 32 | 208.1 | 8.64 | 2.94 | 1.30 | .287 | 80.3% | 40.0% | 12.9% | 92.5 | 3.59 | 3.89 | 4.25 | 4.60 | 4.1 |
| 18 | Merrill Kelly | ARI | 13 | 14 | 0 | 32 | 32 | 183.1 | 7.76 | 2.80 | 1.42 | .292 | 73.1% | 42.0% | 14.8% | 92.1 | 4.42 | 5.37 | 4.51 | 4.58 | 1.9 |
| 19 | Dakota Hudson | STL | 16 | 7 | 1 | 33 | 32 | 174.2 | 7.01 | 4.43 | 1.13 | .274 | 78.1% | 56.9% | 19.8% | 94.1 | 3.35 | 5.09 | 4.93 | 4.55 | 0.9 |
| 20 | Wade Miley | HOU | 14 | 6 | 0 | 33 | 33 | 167.1 | 7.53 | 3.28 | 1.24 | .287 | 74.3% | 49.7% | 15.2% | 90.9 | 3.98 | 4.14 | 4.51 | 4.52 | 2.0 |
| 21 | Homer Bailey | - - - | 13 | 9 | 0 | 31 | 31 | 163.1 | 8.21 | 2.92 | 1.16 | .301 | 71.2% | 44.3% | 12.8% | 93.1 | 4.57 | 4.50 | 4.11 | 4.43 | 2.9 |
| 22 | Adam Wainwright | STL | 14 | 10 | 0 | 31 | 31 | 171.2 | 8.02 | 3.36 | 1.15 | .319 | 76.5% | 48.8% | 15.0% | 89.8 | 4.19 | 4.82 | 4.36 | 4.39 | 2.1 |
| 23 | Joey Lucchesi | SDP | 10 | 10 | 0 | 30 | 30 | 163.2 | 8.69 | 3.08 | 1.26 | .271 | 73.0% | 47.0% | 13.9% | 90.6 | 4.18 | 3.86 | 4.17 | 4.36 | 2.1 |
| 24 | Jon Lester | CHC | 13 | 10 | 0 | 31 | 31 | 171.2 | 8.65 | 2.73 | 1.36 | .347 | 71.4% | 43.3% | 14.6% | 90.7 | 4.46 | 5.09 | 4.26 | 4.35 | 2.8 |
| 25 | Trevor Bauer | - - - | 11 | 13 | 0 | 34 | 34 | 213.0 | 10.69 | 3.46 | 1.44 | .287 | 70.3% | 37.6% | 15.3% | 94.6 | 4.48 | 4.23 | 4.34 | 4.33 | 3.2 |
| 26 | Jose Berrios | MIN | 14 | 8 | 0 | 32 | 32 | 200.1 | 8.76 | 2.29 | 1.17 | .299 | 73.5% | 42.1% | 12.0% | 93.3 | 3.68 | 4.06 | 3.85 | 4.32 | 4.4 |
| 27 | Madison Bumgarner | SFG | 9 | 9 | 0 | 34 | 34 | 207.2 | 8.80 | 1.86 | 1.30 | .289 | 71.8% | 35.8% | 12.6% | 91.6 | 3.90 | 4.57 | 3.90 | 4.31 | 3.3 |
| 28 | Joe Musgrove | PIT | 11 | 12 | 0 | 32 | 31 | 170.1 | 8.30 | 2.06 | 1.11 | .299 | 63.2% | 44.5% | 11.7% | 92.7 | 4.44 | 4.17 | 3.82 | 4.31 | 3.3 |
| 29 | Anthony DeSclafani | CIN | 9 | 9 | 0 | 31 | 31 | 166.2 | 9.02 | 2.65 | 1.57 | .273 | 77.7% | 42.9% | 16.2% | 94.8 | 3.89 | 3.86 | 4.43 | 4.30 | 2.6 |
| 30 | Masahiro Tanaka | NYY | 11 | 9 | 0 | 32 | 31 | 182.0 | 7.37 | 1.98 | 1.38 | .293 | 70.4% | 47.5% | 15.1% | 91.5 | 4.45 | 4.35 | 4.27 | 4.29 | 3.2 |