| 1 | Sandy Alcantara | MIA | 14 | 9 | 0 | 32 | 32 | 228.2 | 8.15 | 1.97 | 0.63 | .262 | 78.8% | 53.4% | 8.5% | 98.0 | 2.28 | 2.92 | 2.99 | 3.29 | 5.7 |
| 2 | Aaron Nola | PHI | 11 | 13 | 0 | 32 | 32 | 205.0 | 10.32 | 1.27 | 0.83 | .289 | 73.0% | 43.6% | 9.8% | 92.9 | 3.25 | 2.74 | 2.58 | 2.77 | 6.3 |
| 3 | Miles Mikolas | STL | 12 | 13 | 0 | 33 | 32 | 202.1 | 6.81 | 1.73 | 1.11 | .249 | 74.4% | 45.0% | 11.9% | 93.6 | 3.29 | 3.89 | 3.87 | 3.80 | 2.8 |
| 4 | Corbin Burnes | MIL | 12 | 8 | 0 | 33 | 33 | 202.0 | 10.83 | 2.27 | 1.02 | .259 | 76.8% | 47.0% | 14.1% | 96.2 | 2.94 | 3.05 | 3.14 | 2.85 | 4.6 |
| 5 | Framber Valdez | HOU | 17 | 6 | 0 | 31 | 31 | 201.1 | 8.67 | 3.00 | 0.49 | .285 | 75.7% | 66.5% | 12.5% | 94.0 | 2.82 | 3.31 | 3.06 | 2.99 | 4.4 |
| 6 | Gerrit Cole | NYY | 13 | 8 | 0 | 33 | 33 | 200.2 | 11.53 | 2.24 | 1.48 | .268 | 78.2% | 42.4% | 16.8% | 97.8 | 3.50 | 3.31 | 3.47 | 2.77 | 3.3 |
| 7 | Merrill Kelly | ARI | 13 | 8 | 0 | 33 | 33 | 200.1 | 7.95 | 2.74 | 0.94 | .269 | 76.3% | 42.8% | 9.9% | 92.4 | 3.37 | 3.62 | 3.65 | 3.86 | 3.3 |
| 8 | Shane Bieber | CLE | 13 | 8 | 0 | 31 | 31 | 200.0 | 8.91 | 1.62 | 0.81 | .287 | 75.8% | 48.2% | 10.4% | 91.5 | 2.88 | 3.51 | 2.87 | 2.98 | 4.9 |
| 9 | Alek Manoah | TOR | 16 | 7 | 0 | 31 | 31 | 196.2 | 8.24 | 2.33 | 0.73 | .244 | 82.6% | 37.5% | 7.1% | 93.9 | 2.24 | 3.31 | 3.35 | 3.97 | 4.1 |
| 10 | Martin Perez | TEX | 12 | 8 | 0 | 32 | 32 | 196.1 | 7.75 | 3.16 | 0.50 | .295 | 77.0% | 51.4% | 6.5% | 92.9 | 2.89 | 3.59 | 3.27 | 3.80 | 3.8 |
| 11 | Yu Darvish | SDP | 16 | 8 | 0 | 30 | 30 | 194.2 | 9.11 | 1.71 | 1.02 | .250 | 78.2% | 36.9% | 9.6% | 95.0 | 3.10 | 3.49 | 3.31 | 3.58 | 4.2 |
| 12 | Logan Webb | SFG | 15 | 9 | 0 | 32 | 32 | 192.1 | 7.63 | 2.29 | 0.51 | .293 | 71.8% | 56.7% | 8.3% | 92.4 | 2.90 | 3.59 | 3.03 | 3.31 | 4.2 |
| 13 | Adam Wainwright | STL | 11 | 12 | 0 | 32 | 32 | 191.2 | 6.71 | 2.54 | 0.75 | .302 | 75.0% | 43.2% | 8.1% | 88.1 | 3.71 | 4.53 | 3.66 | 4.10 | 2.8 |
| 14 | Triston McKenzie | CLE | 11 | 11 | 0 | 31 | 30 | 191.1 | 8.94 | 2.07 | 1.18 | .237 | 80.3% | 32.7% | 10.3% | 92.7 | 2.96 | 3.54 | 3.59 | 3.77 | 3.6 |
| 15 | Robbie Ray | SEA | 12 | 12 | 0 | 32 | 32 | 189.0 | 10.10 | 2.95 | 1.52 | .284 | 81.2% | 39.2% | 15.5% | 93.6 | 3.71 | 3.59 | 4.17 | 3.58 | 1.8 |
| 16 | Cal Quantrill | CLE | 15 | 5 | 0 | 32 | 32 | 186.1 | 6.18 | 2.27 | 1.01 | .278 | 76.4% | 42.1% | 9.6% | 93.9 | 3.38 | 4.31 | 4.12 | 4.39 | 2.2 |
| 17 | Logan Gilbert | SEA | 13 | 6 | 0 | 32 | 32 | 185.2 | 8.43 | 2.38 | 0.92 | .292 | 77.6% | 36.7% | 9.2% | 96.1 | 3.20 | 4.11 | 3.46 | 3.78 | 3.2 |
| 18 | Max Fried | ATL | 14 | 7 | 0 | 30 | 30 | 185.1 | 8.26 | 1.55 | 0.58 | .280 | 78.2% | 51.2% | 7.8% | 94.0 | 2.48 | 2.85 | 2.70 | 3.09 | 5.0 |
| 19 | Dylan Cease | CHW | 14 | 8 | 0 | 32 | 32 | 184.0 | 11.10 | 3.82 | 0.78 | .260 | 82.3% | 38.8% | 8.4% | 96.9 | 2.20 | 2.70 | 3.10 | 3.50 | 4.4 |
| 20 | Zac Gallen | ARI | 12 | 4 | 0 | 31 | 31 | 184.0 | 9.39 | 2.30 | 0.73 | .237 | 78.0% | 46.0% | 9.1% | 93.9 | 2.54 | 3.17 | 3.05 | 3.31 | 4.3 |
| 21 | Marco Gonzales | SEA | 10 | 15 | 0 | 32 | 32 | 183.0 | 5.07 | 2.46 | 1.48 | .277 | 73.7% | 42.0% | 12.3% | 88.7 | 4.13 | 4.59 | 5.05 | 4.90 | 0.1 |
| 22 | Chris Bassitt | NYM | 15 | 9 | 0 | 30 | 30 | 181.2 | 8.27 | 2.43 | 0.94 | .282 | 77.2% | 48.8% | 10.9% | 93.3 | 3.42 | 3.46 | 3.66 | 3.72 | 2.7 |
| 23 | German Marquez | COL | 9 | 13 | 0 | 31 | 31 | 181.2 | 7.43 | 3.12 | 1.49 | .291 | 68.1% | 47.6% | 16.9% | 95.7 | 4.95 | 4.49 | 4.71 | 4.02 | 1.4 |
| 24 | Joe Musgrove | SDP | 10 | 7 | 0 | 30 | 30 | 181.0 | 9.15 | 2.09 | 1.09 | .276 | 79.8% | 44.6% | 12.3% | 92.9 | 2.93 | 3.27 | 3.59 | 3.47 | 3.5 |
| 25 | Cole Irvin | OAK | 9 | 13 | 0 | 30 | 30 | 181.0 | 6.36 | 1.79 | 1.24 | .273 | 71.4% | 37.7% | 10.5% | 90.9 | 3.98 | 4.40 | 4.21 | 4.35 | 1.4 |
| 26 | Kyle Wright | ATL | 21 | 5 | 0 | 30 | 30 | 180.1 | 8.68 | 2.65 | 0.95 | .284 | 78.9% | 55.6% | 14.4% | 95.1 | 3.19 | 3.89 | 3.58 | 3.30 | 2.9 |
| 27 | Pablo Lopez | MIA | 10 | 10 | 0 | 32 | 32 | 180.0 | 8.70 | 2.65 | 1.05 | .283 | 74.2% | 46.1% | 12.7% | 93.5 | 3.75 | 3.75 | 3.71 | 3.56 | 2.8 |
| 28 | Nick Pivetta | BOS | 10 | 12 | 0 | 33 | 33 | 179.2 | 8.77 | 3.66 | 1.35 | .300 | 75.3% | 38.5% | 12.4% | 93.6 | 4.56 | 4.65 | 4.42 | 4.26 | 1.5 |
| 29 | Jordan Lyles | BAL | 12 | 11 | 0 | 32 | 32 | 179.0 | 7.24 | 2.61 | 1.31 | .313 | 73.8% | 40.2% | 11.4% | 91.9 | 4.42 | 4.94 | 4.40 | 4.39 | 1.4 |
| 30 | Tyler Anderson | LAD | 15 | 5 | 0 | 30 | 28 | 178.2 | 6.95 | 1.71 | 0.71 | .256 | 77.8% | 40.1% | 6.4% | 90.7 | 2.57 | 3.10 | 3.31 | 4.10 | 4.0 |