| 1 | Francisco Liriano | PIT | 16 | 8 | 0 | 26 | 26 | 161.0 | 9.11 | 3.52 | 0.50 | .290 | 77.5% | 50.5% | 8.3% | | 3.02 | | 2.92 | 3.12 | 3.1 |
| 2 | Kenley Jansen | LAD | 4 | 3 | 28 | 75 | 0 | 76.2 | 13.03 | 2.11 | 0.70 | .273 | 87.5% | 37.3% | 9.8% | | 1.88 | | 1.99 | 2.06 | 2.4 |
| 3 | Kyle Kendrick | PHI | 10 | 13 | 0 | 30 | 30 | 182.0 | 5.44 | 2.32 | 0.89 | .306 | 66.6% | 49.4% | 9.5% | | 4.70 | | 4.01 | 4.15 | 2.0 |
| 4 | Chris Capuano | LAD | 4 | 7 | 0 | 24 | 20 | 105.2 | 6.90 | 2.04 | 0.94 | .334 | 68.9% | 46.4% | 9.6% | | 4.26 | | 3.55 | 3.67 | 1.3 |
| 5 | Josh Collmenter | ARI | 5 | 5 | 0 | 49 | 0 | 92.0 | 8.32 | 3.23 | 0.78 | .277 | 77.8% | 32.7% | 6.9% | | 3.13 | | 3.47 | 4.06 | 0.9 |
| 6 | J.P. Howell | LAD | 4 | 1 | 0 | 67 | 0 | 62.0 | 7.84 | 3.34 | 0.29 | .241 | 80.7% | 57.2% | 4.3% | | 2.18 | | 2.89 | 3.48 | 0.8 |
| 7 | Will Harris | ARI | 4 | 1 | 0 | 61 | 0 | 52.2 | 9.06 | 2.56 | 0.51 | .326 | 79.6% | 47.3% | 7.0% | | 2.91 | | 2.74 | 3.12 | 0.8 |
| 8 | Tony Watson | PIT | 3 | 1 | 2 | 67 | 0 | 71.2 | 6.78 | 1.51 | 0.63 | .227 | 80.6% | 43.8% | 6.7% | | 2.39 | | 3.20 | 3.72 | 0.6 |
| 9 | Chad Qualls | MIA | 5 | 2 | 0 | 66 | 0 | 62.0 | 7.11 | 2.76 | 0.58 | .298 | 82.9% | 63.3% | 11.4% | | 2.61 | | 3.32 | 3.25 | 0.5 |
| 10 | Jeff Francis | COL | 3 | 5 | 0 | 23 | 12 | 70.1 | 8.06 | 3.07 | 1.54 | .344 | 61.7% | 46.8% | 15.6% | | 6.27 | | 4.54 | 3.82 | 0.4 |
| 11 | Jeanmar Gomez | PIT | 3 | 0 | 0 | 34 | 8 | 80.2 | 5.91 | 3.12 | 0.67 | .243 | 69.6% | 55.4% | 9.5% | | 3.35 | | 3.85 | 3.95 | 0.2 |
| 12 | Jake Westbrook | STL | 7 | 8 | 0 | 21 | 19 | 116.2 | 3.39 | 3.86 | 0.54 | .303 | 67.5% | 56.3% | 7.4% | | 4.63 | | 4.62 | 4.95 | -0.1 |
| 13 | Roy Halladay | PHI | 4 | 5 | 0 | 13 | 13 | 62.0 | 7.40 | 5.23 | 1.74 | .249 | 62.9% | 40.7% | 17.9% | | 6.82 | | 6.14 | 5.10 | -0.7 |
| 14 | Brandon League | LAD | 6 | 4 | 14 | 58 | 0 | 54.1 | 4.64 | 2.48 | 1.33 | .313 | 66.0% | 59.8% | 19.0% | | 5.30 | | 4.93 | 4.07 | -0.7 |
| 15 | Jason Marquis | SDP | 9 | 5 | 0 | 20 | 20 | 117.2 | 5.51 | 5.20 | 1.38 | .261 | 77.3% | 52.3% | 18.2% | | 4.05 | | 5.65 | 4.81 | -1.3 |
| 16 | Brad Ziegler | ARI | 8 | 1 | 13 | 78 | 0 | 73.0 | 5.42 | 2.71 | 0.37 | .258 | 80.7% | 70.4% | 12.5% | 78.9 | 2.22 | | 3.40 | 3.32 | 0.5 |
| 17 | Barry Zito | SFG | 5 | 11 | 0 | 30 | 25 | 133.1 | 5.80 | 3.64 | 1.28 | .346 | 67.0% | 36.3% | 11.1% | 84.2 | 5.74 | | 4.92 | 4.81 | -0.7 |
| 18 | Shaun Marcum | NYM | 1 | 10 | 0 | 14 | 12 | 78.1 | 6.89 | 2.41 | 0.80 | .322 | 61.9% | 34.9% | 7.0% | 86.1 | 5.29 | | 3.64 | 4.22 | 1.6 |
| 19 | Tyler Cloyd | PHI | 2 | 7 | 0 | 13 | 11 | 60.1 | 6.12 | 3.73 | 1.04 | .365 | 64.5% | 39.4% | 8.9% | 87.5 | 6.56 | | 4.49 | 4.77 | 0.3 |
| 20 | Eric Stults | SDP | 11 | 13 | 0 | 33 | 33 | 203.2 | 5.79 | 1.77 | 0.80 | .302 | 69.6% | 40.4% | 6.9% | 87.8 | 3.93 | | 3.53 | 4.13 | 3.2 |
| 21 | Paul Maholm | ATL | 10 | 11 | 0 | 26 | 26 | 153.0 | 6.18 | 2.76 | 1.00 | .310 | 71.2% | 51.3% | 13.8% | 88.4 | 4.41 | | 4.24 | 3.89 | 0.6 |
| 22 | John Lannan | PHI | 3 | 6 | 0 | 14 | 14 | 74.1 | 4.60 | 3.27 | 0.73 | .313 | 63.9% | 52.4% | 7.9% | 88.5 | 5.33 | | 4.37 | 4.71 | 0.5 |
| 23 | Bronson Arroyo | CIN | 14 | 12 | 0 | 32 | 32 | 202.0 | 5.52 | 1.51 | 1.43 | .267 | 77.9% | 44.4% | 14.0% | 88.6 | 3.79 | | 4.49 | 3.97 | 1.2 |
| 24 | Chris Rusin | CHC | 2 | 6 | 0 | 13 | 13 | 66.1 | 4.88 | 3.26 | 1.09 | .275 | 77.0% | 48.1% | 12.9% | 88.7 | 3.93 | | 4.75 | 4.46 | 0.2 |
| 25 | Clayton Richard | SDP | 2 | 5 | 0 | 12 | 11 | 52.2 | 4.10 | 3.59 | 2.22 | .287 | 61.9% | 51.9% | 25.5% | 88.8 | 7.01 | | 6.54 | 4.66 | -1.0 |
| 26 | Carlos Villanueva | CHC | 7 | 8 | 0 | 47 | 15 | 128.2 | 7.20 | 2.80 | 0.98 | .283 | 72.6% | 40.0% | 9.8% | 89.0 | 4.06 | | 3.86 | 3.97 | 1.2 |
| 27 | Jaime Garcia | STL | 5 | 2 | 0 | 9 | 9 | 55.1 | 6.99 | 2.44 | 0.98 | .300 | 72.3% | 63.0% | 15.4% | 89.1 | 3.58 | | 3.72 | 3.27 | 0.5 |
| 28 | Jon Garland | COL | 4 | 6 | 0 | 12 | 12 | 68.0 | 4.24 | 3.04 | 1.19 | .321 | 66.7% | 49.1% | 13.6% | 89.1 | 5.82 | | 4.93 | 4.54 | 0.3 |
| 29 | Sergio Romo | SFG | 5 | 8 | 38 | 65 | 0 | 60.1 | 8.65 | 1.79 | 0.75 | .276 | 78.0% | 40.7% | 7.9% | 89.2 | 2.54 | | 2.85 | 3.20 | 1.0 |
| 30 | Marco Estrada | MIL | 7 | 4 | 0 | 21 | 21 | 128.0 | 8.30 | 2.04 | 1.34 | .262 | 74.1% | 37.6% | 11.9% | 89.9 | 3.87 | | 3.86 | 3.63 | 1.4 |