| 1 | 2016 | Mark Melancon | - - - | 2 | 2 | 47 | 75 | 0 | 71.1 | 8.20 | 1.51 | 0.38 | .259 | 80.6% | 54.2% | 6.3% | 92.3 | 1.64 | 2.52 | 2.42 | 2.99 | 1.8 |
| 2 | 2016 | Clayton Kershaw | LAD | 12 | 4 | 0 | 21 | 21 | 149.0 | 10.39 | 0.66 | 0.48 | .254 | 80.0% | 49.4% | 7.5% | 93.8 | 1.69 | 2.05 | 1.80 | 2.28 | 6.3 |
| 3 | 2016 | Seunghwan Oh | STL | 6 | 3 | 19 | 76 | 0 | 79.2 | 11.64 | 2.03 | 0.56 | .270 | 80.9% | 40.0% | 6.7% | 93.8 | 1.92 | 2.12 | 2.13 | 2.88 | 2.6 |
| 4 | 2016 | Addison Reed | NYM | 4 | 2 | 1 | 80 | 0 | 77.2 | 10.55 | 1.51 | 0.46 | .286 | 81.6% | 39.5% | 5.4% | 93.2 | 1.97 | 2.82 | 1.97 | 2.89 | 2.4 |
| 5 | 2016 | Kyle Hendricks | CHC | 16 | 8 | 0 | 31 | 30 | 190.0 | 8.05 | 2.08 | 0.71 | .250 | 81.5% | 48.4% | 9.3% | 88.9 | 2.13 | 2.78 | 3.20 | 3.59 | 4.2 |
| 6 | 2016 | David Phelps | MIA | 7 | 6 | 4 | 64 | 5 | 86.2 | 11.84 | 3.95 | 0.62 | .286 | 84.2% | 46.2% | 9.2% | 94.4 | 2.28 | 2.78 | 2.80 | 3.15 | 2.1 |
| 7 | 2016 | Jon Lester | CHC | 19 | 5 | 0 | 32 | 32 | 202.2 | 8.75 | 2.31 | 0.93 | .256 | 84.9% | 46.9% | 12.2% | 93.1 | 2.44 | 3.07 | 3.41 | 3.47 | 4.2 |
| 8 | 2016 | Drew Pomeranz | SDP | 8 | 7 | 0 | 17 | 17 | 102.0 | 10.15 | 3.62 | 0.71 | .240 | 80.8% | 47.8% | 8.8% | 91.7 | 2.47 | 3.24 | 3.15 | 3.61 | 2.4 |
| 9 | 2016 | Joe Blanton | LAD | 7 | 2 | 0 | 75 | 0 | 80.0 | 9.00 | 2.93 | 0.79 | .240 | 82.0% | 32.5% | 7.4% | 91.9 | 2.48 | 3.28 | 3.33 | 4.15 | 0.7 |
| 10 | 2016 | Raisel Iglesias | CIN | 3 | 2 | 6 | 37 | 5 | 78.1 | 9.54 | 2.99 | 0.80 | .275 | 85.5% | 40.6% | 8.9% | 95.0 | 2.53 | 2.91 | 3.38 | 3.89 | 1.5 |
| 11 | 2016 | Jeurys Familia | NYM | 3 | 4 | 51 | 78 | 0 | 77.2 | 9.73 | 3.59 | 0.12 | .304 | 74.8% | 63.3% | 2.6% | 97.6 | 2.55 | 2.50 | 2.39 | 3.03 | 2.1 |
| 12 | 2016 | Hector Neris | PHI | 4 | 4 | 2 | 79 | 0 | 80.1 | 11.43 | 3.36 | 1.01 | .272 | 83.1% | 41.9% | 14.1% | 94.8 | 2.58 | 3.48 | 3.30 | 3.17 | 1.3 |
| 13 | 2016 | Noah Syndergaard | NYM | 14 | 9 | 0 | 31 | 30 | 183.2 | 10.68 | 2.11 | 0.54 | .334 | 76.9% | 51.2% | 8.6% | 98.9 | 2.60 | 2.78 | 2.29 | 2.67 | 6.0 |
| 14 | 2016 | Carlos Torres | MIL | 3 | 3 | 2 | 72 | 0 | 82.1 | 8.53 | 3.28 | 0.87 | .260 | 83.1% | 44.6% | 10.4% | 92.9 | 2.73 | 3.77 | 3.75 | 4.05 | 0.6 |
| 15 | 2016 | Madison Bumgarner | SFG | 15 | 9 | 0 | 34 | 34 | 226.2 | 9.97 | 2.14 | 1.03 | .265 | 79.1% | 39.6% | 10.7% | 91.6 | 2.74 | 3.24 | 3.24 | 3.54 | 4.3 |
| 16 | 2016 | Johnny Cueto | SFG | 18 | 5 | 0 | 32 | 32 | 219.2 | 8.11 | 1.84 | 0.61 | .293 | 78.0% | 50.2% | 8.4% | 92.5 | 2.79 | 3.53 | 2.96 | 3.42 | 4.9 |
| 17 | 2016 | Junior Guerra | MIL | 9 | 3 | 0 | 20 | 20 | 121.2 | 7.40 | 3.18 | 0.74 | .250 | 79.4% | 45.3% | 8.3% | 93.8 | 2.81 | 3.88 | 3.71 | 4.29 | 2.3 |
| 18 | 2016 | Tanner Roark | WSN | 16 | 10 | 0 | 34 | 33 | 210.0 | 7.37 | 3.13 | 0.73 | .269 | 79.5% | 48.7% | 9.4% | 93.0 | 2.83 | 3.93 | 3.79 | 4.17 | 3.3 |
| 19 | 2016 | Kyle Barraclough | MIA | 6 | 3 | 0 | 75 | 0 | 72.2 | 14.00 | 5.45 | 0.12 | .301 | 74.8% | 52.1% | 2.6% | 96.3 | 2.85 | 2.59 | 2.11 | 2.83 | 2.2 |
| 20 | 2016 | Jose Fernandez | MIA | 16 | 8 | 0 | 29 | 29 | 182.1 | 12.49 | 2.71 | 0.64 | .332 | 76.6% | 40.2% | 10.0% | 96.0 | 2.86 | 3.00 | 2.30 | 2.56 | 6.3 |
| 21 | 2016 | Brad Hand | SDP | 4 | 4 | 1 | 82 | 0 | 89.1 | 11.18 | 3.63 | 0.81 | .264 | 76.6% | 46.7% | 10.4% | 93.5 | 2.92 | 2.98 | 3.07 | 3.34 | 1.5 |
| 22 | 2016 | Max Scherzer | WSN | 20 | 7 | 0 | 34 | 34 | 228.1 | 11.19 | 2.21 | 1.22 | .255 | 81.7% | 33.0% | 11.9% | 95.1 | 2.96 | 2.78 | 3.24 | 3.37 | 5.6 |
| 23 | 2016 | Jacob deGrom | NYM | 7 | 8 | 0 | 24 | 24 | 148.0 | 8.70 | 2.19 | 0.91 | .312 | 80.0% | 45.6% | 11.5% | 94.2 | 3.04 | 4.02 | 3.32 | 3.47 | 2.9 |
| 24 | 2016 | Pedro Baez | LAD | 3 | 2 | 0 | 73 | 0 | 74.0 | 10.09 | 2.68 | 1.34 | .232 | 80.9% | 42.6% | 15.9% | 97.5 | 3.04 | 3.36 | 3.81 | 3.43 | 0.3 |
| 25 | 2016 | Carlos Martinez | STL | 16 | 9 | 0 | 31 | 31 | 195.1 | 8.02 | 3.23 | 0.69 | .286 | 79.5% | 56.4% | 10.6% | 97.2 | 3.04 | 3.33 | 3.61 | 3.81 | 3.2 |
| 26 | 2016 | Jake Arrieta | CHC | 18 | 8 | 0 | 31 | 31 | 197.1 | 8.67 | 3.47 | 0.73 | .241 | 74.9% | 52.6% | 11.1% | 94.4 | 3.10 | 3.56 | 3.52 | 3.68 | 3.5 |
| 27 | 2016 | Julio Teheran | ATL | 7 | 10 | 0 | 30 | 30 | 188.0 | 7.99 | 1.96 | 1.05 | .260 | 77.8% | 39.1% | 10.0% | 91.7 | 3.21 | 3.72 | 3.69 | 4.13 | 3.0 |
| 28 | 2016 | Anthony DeSclafani | CIN | 9 | 5 | 0 | 20 | 20 | 123.1 | 7.66 | 2.19 | 1.17 | .295 | 78.3% | 41.9% | 12.6% | 93.7 | 3.28 | 3.88 | 3.96 | 3.99 | 2.1 |
| 29 | 2016 | John Lackey | CHC | 11 | 8 | 0 | 29 | 29 | 188.1 | 8.60 | 2.53 | 1.10 | .255 | 76.2% | 41.0% | 12.9% | 92.5 | 3.35 | 4.22 | 3.81 | 3.80 | 2.9 |
| 30 | 2016 | Jameson Taillon | PIT | 5 | 4 | 0 | 18 | 18 | 104.0 | 7.36 | 1.47 | 1.13 | .287 | 78.4% | 52.4% | 15.5% | 95.0 | 3.38 | 3.33 | 3.71 | 3.43 | 1.7 |