| 1 | Jon Lester | 13 | 8 | 0 | 32 | 32 | 180.2 | 8.97 | 2.99 | 1.30 | .310 | 68.7% | 46.2% | 15.8% | 91.9 | 4.33 | 3.95 | 4.10 | 3.85 | 2.9 |
| 2 | Jake Arrieta | 14 | 10 | 0 | 30 | 30 | 168.1 | 8.71 | 2.94 | 1.23 | .279 | 72.8% | 45.1% | 14.0% | 92.4 | 3.53 | 3.98 | 4.16 | 4.11 | 2.5 |
| 3 | Kyle Hendricks | 7 | 5 | 0 | 24 | 24 | 139.2 | 7.93 | 2.58 | 1.10 | .281 | 82.5% | 50.1% | 14.8% | 86.4 | 3.03 | 3.92 | 3.88 | 3.76 | 2.5 |
| 4 | Jose Quintana | 7 | 3 | 0 | 14 | 14 | 84.1 | 10.46 | 2.24 | 0.96 | .300 | 72.4% | 47.2% | 13.8% | 92.8 | 3.74 | | 3.25 | 3.24 | 2.1 |
| 5 | Mike Montgomery | 5 | 5 | 0 | 14 | 14 | 69.1 | 7.27 | 2.73 | 0.91 | .258 | 68.3% | 59.2% | 13.0% | 91.9 | 4.15 | | 3.94 | 4.01 | 1.1 |
| 6 | Eddie Butler | 4 | 3 | 0 | 11 | 11 | 51.1 | 5.08 | 4.73 | 0.53 | .272 | 75.2% | 44.4% | 5.6% | 93.4 | 3.86 | | 4.48 | 5.59 | 0.7 |
| 7 | John Lackey | 12 | 11 | 0 | 30 | 30 | 169.2 | 7.85 | 2.81 | 1.91 | .266 | 76.6% | 41.4% | 18.3% | 91.5 | 4.56 | | 5.32 | 4.63 | 0.5 |
| 8 | Brett Anderson | 2 | 2 | 0 | 6 | 6 | 22.0 | 6.55 | 4.91 | 0.82 | .395 | 55.6% | 50.0% | 14.3% | 91.1 | 8.18 | | 4.52 | 4.47 | 0.2 |
| 9 | Jen-Ho Tseng | 0 | 0 | 0 | 1 | 1 | 3.0 | 18.00 | 3.00 | 6.00 | .429 | 47.6% | 44.4% | 66.7% | 91.7 | 15.00 | | 9.82 | 2.94 | -0.1 |