| 1 | Tim Hudson | ATL | .249 | 2.87 | 13.6% | 64.1% | 22.3% | 5.9% | 13.1% | 125 | 4.92 | 1269 | 2070 | 3339 | 37.2% | 42.7% | 20.1% | 17.6% | 55.0% | 27.4% |
| 2 | Derek Lowe | ATL | .307 | 2.61 | 18.6% | 58.8% | 22.6% | 3.6% | 13.1% | 113 | 5.25 | 1242 | 1924 | 3166 | 43.7% | 38.0% | 18.3% | 15.4% | 52.8% | 31.8% |
| 3 | Justin Masterson | CLE | .326 | 2.49 | 15.4% | 60.3% | 24.2% | 5.4% | 10.9% | 86 | 4.57 | 1122 | 1813 | 2935 | 43.9% | 34.7% | 21.4% | 15.0% | 53.0% | 32.0% |
| 4 | Jaime Garcia | STL | .292 | 2.19 | 18.6% | 55.9% | 25.6% | 4.0% | 7.3% | 97 | 5.34 | 977 | 1632 | 2609 | 42.5% | 36.1% | 21.4% | 17.1% | 57.1% | 25.8% |
| 5 | Jake Westbrook | - - - | .288 | 2.14 | 17.3% | 56.4% | 26.3% | 4.7% | 11.7% | 103 | 4.57 | 1289 | 2044 | 3333 | 39.3% | 33.5% | 27.1% | 18.8% | 50.9% | 30.3% |
| 6 | Ricky Romero | TOR | .289 | 2.08 | 18.2% | 55.2% | 26.5% | 6.9% | 9.4% | 121 | 5.19 | 1259 | 1982 | 3241 | 41.4% | 38.8% | 19.7% | 15.4% | 57.4% | 27.2% |
| 7 | R.A. Dickey | NYM | .277 | 1.99 | 16.9% | 55.3% | 27.8% | 10.6% | 8.6% | 82 | 4.26 | 881 | 1713 | 2594 | 38.0% | 35.7% | 26.4% | 21.9% | 49.2% | 28.9% |
| 8 | Francisco Liriano | MIN | .331 | 1.96 | 19.1% | 53.6% | 27.4% | 9.9% | 6.3% | 111 | 5.21 | 1080 | 1941 | 3021 | 41.5% | 35.0% | 23.5% | 16.9% | 55.7% | 27.4% |
| 9 | Trevor Cahill | OAK | .236 | 1.93 | 15.0% | 56.0% | 29.0% | 5.3% | 11.2% | 112 | 5.13 | 1219 | 1819 | 3038 | 39.4% | 39.4% | 21.1% | 18.1% | 52.9% | 29.0% |
| 10 | Jon Lester | BOS | .289 | 1.81 | 16.9% | 53.6% | 29.6% | 8.2% | 8.9% | 132 | 5.71 | 1289 | 2068 | 3357 | 47.1% | 33.0% | 19.9% | 18.0% | 59.3% | 22.7% |
| 11 | Felix Hernandez | SEA | .263 | 1.81 | 16.3% | 53.9% | 29.8% | 9.0% | 8.5% | 86 | 3.10 | 1320 | 2411 | 3731 | 37.8% | 34.7% | 27.5% | 16.9% | 55.9% | 27.2% |
| 12 | Roberto Hernandez | CLE | .283 | 1.81 | 13.6% | 55.6% | 30.8% | 11.7% | 8.3% | 93 | 3.98 | 1246 | 2058 | 3304 | 44.7% | 35.1% | 20.1% | 16.1% | 54.1% | 29.8% |
| 13 | Roy Halladay | PHI | .290 | 1.72 | 19.1% | 51.2% | 29.7% | 8.9% | 11.3% | 138 | 4.95 | 1127 | 2441 | 3568 | 37.0% | 41.2% | 21.8% | 18.4% | 57.2% | 24.4% |
| 14 | Jon Garland | SDP | .265 | 1.71 | 17.8% | 51.9% | 30.3% | 9.4% | 11.0% | 87 | 3.92 | 1259 | 1994 | 3253 | 41.9% | 32.9% | 25.2% | 16.3% | 52.5% | 31.3% |
| 15 | Paul Maholm | PIT | .327 | 1.69 | 18.9% | 50.9% | 30.1% | 5.2% | 7.7% | 84 | 4.08 | 1170 | 1898 | 3068 | 40.5% | 34.9% | 24.6% | 16.5% | 51.0% | 32.5% |
| 16 | Adam Wainwright | STL | .275 | 1.68 | 17.6% | 51.6% | 30.7% | 6.8% | 7.9% | 142 | 5.55 | 1190 | 2166 | 3356 | 39.2% | 38.1% | 22.6% | 19.8% | 56.2% | 24.0% |
| 17 | Carl Pavano | MIN | .281 | 1.66 | 17.8% | 51.2% | 30.9% | 7.0% | 10.6% | 130 | 5.29 | 1012 | 2127 | 3139 | 43.6% | 34.2% | 22.3% | 11.5% | 54.8% | 33.6% |
| 18 | Clay Buchholz | BOS | .261 | 1.61 | 17.7% | 50.8% | 31.5% | 8.1% | 5.6% | 109 | 5.65 | 1073 | 1737 | 2810 | 39.3% | 37.4% | 23.3% | 19.1% | 54.5% | 26.4% |
| 19 | Hiroki Kuroda | LAD | .283 | 1.59 | 16.8% | 51.1% | 32.1% | 16.6% | 8.0% | 94 | 4.31 | 1099 | 1929 | 3028 | 36.6% | 38.8% | 24.6% | 24.7% | 49.0% | 26.3% |
| 20 | Chris Carpenter | STL | .278 | 1.58 | 16.7% | 51.1% | 32.2% | 7.1% | 9.3% | 119 | 4.56 | 1294 | 2255 | 3549 | 44.4% | 35.0% | 20.6% | 16.7% | 52.4% | 31.0% |
| 21 | Rick Porcello | DET | .307 | 1.57 | 17.6% | 50.3% | 32.1% | 7.7% | 9.9% | 95 | 5.26 | 949 | 1642 | 2591 | 41.0% | 34.2% | 24.9% | 15.8% | 54.6% | 29.6% |
| 22 | Gavin Floyd | CHW | .325 | 1.55 | 18.0% | 49.9% | 32.1% | 6.0% | 7.6% | 82 | 3.94 | 1160 | 1860 | 3020 | 40.8% | 32.8% | 26.4% | 15.8% | 53.5% | 30.7% |
| 23 | Edwin Jackson | - - - | .313 | 1.55 | 18.8% | 49.4% | 31.9% | 6.5% | 10.6% | 110 | 4.73 | 1272 | 2086 | 3358 | 45.5% | 29.8% | 24.6% | 17.0% | 51.0% | 32.0% |
| 24 | Tim Lincecum | SFG | .310 | 1.55 | 19.5% | 48.9% | 31.6% | 7.2% | 9.9% | 115 | 4.87 | 1227 | 2210 | 3437 | 40.7% | 37.6% | 21.7% | 14.5% | 52.5% | 33.0% |
| 25 | Chad Billingsley | LAD | .301 | 1.54 | 18.3% | 49.6% | 32.1% | 6.7% | 4.5% | 85 | 3.99 | 1160 | 1974 | 3134 | 39.5% | 35.8% | 24.7% | 18.3% | 53.3% | 28.4% |
| 26 | Jon Niese | NYM | .324 | 1.50 | 20.6% | 47.7% | 31.8% | 9.4% | 11.8% | 100 | 5.18 | 1063 | 1884 | 2947 | 42.1% | 34.3% | 23.6% | 18.5% | 45.4% | 36.1% |
| 27 | Wandy Rodriguez | HOU | .303 | 1.49 | 20.0% | 47.9% | 32.1% | 10.2% | 9.0% | 98 | 4.52 | 1213 | 1992 | 3205 | 39.8% | 37.5% | 22.8% | 18.9% | 48.9% | 32.2% |
| 28 | CC Sabathia | NYY | .281 | 1.49 | 15.1% | 50.7% | 34.1% | 9.9% | 8.6% | 162 | 6.13 | 1316 | 2271 | 3587 | 35.8% | 37.0% | 27.2% | 23.4% | 51.7% | 24.9% |
| 29 | Mike Pelfrey | NYM | .300 | 1.49 | 20.3% | 47.6% | 32.0% | 6.7% | 5.8% | 94 | 4.17 | 1270 | 2119 | 3389 | 32.4% | 40.3% | 27.3% | 18.7% | 51.6% | 29.6% |
| 30 | C.J. Wilson | TEX | .266 | 1.47 | 17.3% | 49.2% | 33.5% | 4.2% | 5.3% | 97 | 4.28 | 1389 | 2052 | 3441 | 39.2% | 36.7% | 24.1% | 15.6% | 55.3% | 29.1% |