ZiPS Projections Courtesy of Dan Szymborski
| Zack Wheeler | PHI | 16 | 16 | 101.0 | 8 | 4 | | | 88 | 35 | 8 | 108 | 24 | 1.11 | 9.66 | 2.14 | 3.16 | 2.91 | 2.7 | 2.6 |
| Gerrit Cole | NYY | 16 | 16 | 98.0 | 8 | 3 | | | 77 | 33 | 12 | 132 | 26 | 1.05 | 12.16 | 2.36 | 3.02 | 2.85 | 2.7 | 2.3 |
| Corbin Burnes | MIL | 15 | 15 | 88.0 | 7 | 3 | | | 68 | 29 | 9 | 115 | 25 | 1.06 | 11.82 | 2.58 | 2.97 | 2.80 | 2.4 | 2.6 |
| Aaron Nola | PHI | 17 | 17 | 102.0 | 7 | 4 | | | 86 | 38 | 13 | 119 | 24 | 1.08 | 10.55 | 2.15 | 3.34 | 3.26 | 2.3 | 2.4 |
| Kevin Gausman | TOR | 16 | 16 | 94.0 | 7 | 3 | | | 82 | 33 | 10 | 101 | 21 | 1.09 | 9.64 | 1.98 | 3.19 | 3.04 | 2.2 | 2.2 |
| Sandy Alcantara | MIA | 18 | 18 | 110.0 | 7 | 5 | | | 96 | 42 | 9 | 109 | 32 | 1.17 | 8.84 | 2.64 | 3.40 | 3.28 | 2.2 | 2.2 |
| Shane Bieber | CLE | 14 | 14 | 85.0 | 6 | 3 | | | 75 | 30 | 9 | 104 | 20 | 1.12 | 10.97 | 2.14 | 3.19 | 2.92 | 2.1 | 1.8 |
| Max Fried | ATL | 15 | 15 | 91.0 | 8 | 3 | | | 80 | 32 | 8 | 88 | 20 | 1.10 | 8.74 | 1.97 | 3.12 | 3.08 | 2.1 | 2.5 |
| Dylan Cease | CHW | 18 | 18 | 92.0 | 7 | 4 | | | 75 | 37 | 10 | 121 | 43 | 1.28 | 11.87 | 4.18 | 3.65 | 3.44 | 1.9 | 1.5 |
| Logan Webb | SFG | 15 | 16 | 86.0 | 6 | 3 | | | 79 | 30 | 6 | 86 | 22 | 1.17 | 9.02 | 2.30 | 3.17 | 2.95 | 1.9 | 2.0 |
| Walker Buehler | LAD | 17 | 17 | 98.0 | 7 | 3 | | | 82 | 37 | 12 | 102 | 24 | 1.08 | 9.37 | 2.21 | 3.38 | 3.46 | 1.9 | 2.1 |
| Luis Castillo | CIN | 16 | 16 | 91.0 | 7 | 4 | | | 81 | 36 | 9 | 99 | 34 | 1.26 | 9.76 | 3.32 | 3.56 | 3.45 | 1.9 | 2.1 |
| Max Scherzer | NYM | 14 | 14 | 82.0 | 6 | 3 | | | 63 | 28 | 11 | 110 | 20 | 1.02 | 12.08 | 2.25 | 3.10 | 3.12 | 1.9 | 1.9 |
| Carlos Rodón | SFG | 13 | 13 | 72.0 | 7 | 3 | | | 58 | 25 | 6 | 89 | 25 | 1.15 | 11.21 | 3.09 | 3.18 | 2.91 | 1.8 | 1.8 |
| Brandon Woodruff | MIL | 14 | 14 | 76.0 | 6 | 3 | | | 62 | 27 | 8 | 92 | 20 | 1.07 | 10.86 | 2.31 | 3.23 | 3.04 | 1.8 | 1.9 |
| Tyler Mahle | CIN | 18 | 18 | 95.0 | 6 | 5 | | | 89 | 43 | 12 | 107 | 35 | 1.30 | 10.11 | 3.29 | 4.05 | 3.77 | 1.8 | 1.5 |
| Lucas Giolito | CHW | 16 | 16 | 94.0 | 6 | 5 | | | 77 | 39 | 14 | 114 | 31 | 1.15 | 10.97 | 2.96 | 3.75 | 3.69 | 1.7 | 1.3 |
| Joe Musgrove | SDP | 16 | 16 | 91.0 | 7 | 4 | | | 79 | 35 | 11 | 99 | 23 | 1.13 | 9.74 | 2.31 | 3.45 | 3.46 | 1.7 | 1.8 |
| Julio Urías | LAD | 16 | 17 | 91.0 | 8 | 4 | | | 80 | 36 | 12 | 93 | 21 | 1.12 | 9.18 | 2.09 | 3.56 | 3.59 | 1.7 | 1.7 |
| Frankie Montas | OAK | 16 | 16 | 94.0 | 7 | 4 | | | 86 | 37 | 12 | 102 | 27 | 1.20 | 9.77 | 2.55 | 3.52 | 3.50 | 1.7 | 1.5 |
| Justin Verlander | HOU | 14 | 14 | 86.0 | 8 | 4 | | | 68 | 32 | 14 | 100 | 17 | 0.98 | 10.41 | 1.76 | 3.34 | 3.70 | 1.6 | 1.6 |
| Freddy Peralta | MIL | 12 | 16 | 68.0 | 5 | 3 | | | 49 | 26 | 7 | 93 | 28 | 1.14 | 12.28 | 3.69 | 3.42 | 3.23 | 1.6 | 1.5 |
| Eduardo Rodriguez | DET | 14 | 15 | 78.0 | 5 | 4 | | | 74 | 32 | 8 | 81 | 25 | 1.28 | 9.45 | 2.95 | 3.68 | 3.46 | 1.5 | 1.3 |
| Charlie Morton | ATL | 16 | 16 | 90.0 | 6 | 3 | | | 77 | 36 | 10 | 101 | 31 | 1.21 | 10.17 | 3.14 | 3.66 | 3.66 | 1.4 | 1.8 |
| Robbie Ray | SEA | 16 | 16 | 93.0 | 6 | 4 | | | 75 | 38 | 15 | 117 | 30 | 1.12 | 11.23 | 2.89 | 3.62 | 3.75 | 1.4 | 1.2 |
| Germán Márquez | COL | 16 | 16 | 93.0 | 5 | 6 | | | 95 | 47 | 13 | 91 | 30 | 1.35 | 8.77 | 2.92 | 4.55 | 4.00 | 1.4 | 1.4 |
| Nathan Eovaldi | BOS | 14 | 15 | 81.0 | 5 | 4 | | | 82 | 37 | 12 | 88 | 18 | 1.23 | 9.76 | 1.98 | 4.15 | 3.64 | 1.4 | 0.9 |
| Clayton Kershaw | LAD | 12 | 12 | 69.0 | 6 | 3 | | | 59 | 26 | 10 | 76 | 14 | 1.07 | 9.95 | 1.90 | 3.35 | 3.46 | 1.3 | 1.5 |
| Alek Manoah | TOR | 14 | 14 | 74.0 | 6 | 3 | | | 61 | 28 | 7 | 81 | 23 | 1.15 | 9.82 | 2.84 | 3.39 | 3.56 | 1.3 | 1.6 |
| Shohei Ohtani | LAA | 12 | 12 | 63.0 | 4 | 3 | | | 52 | 24 | 7 | 77 | 21 | 1.16 | 11.06 | 3.00 | 3.49 | 3.35 | 1.3 | 1.2 |