ZiPS Projections Courtesy of Dan Szymborski
| Kevin Gausman | TOR | 31 | 31 | 183.0 | 14 | 8 | | | 163 | 60 | 15 | 203 | 32 | 1.07 | 9.98 | 1.57 | 2.94 | 2.54 | 5.3 | 4.6 |
| Gerrit Cole | NYY | 32 | 32 | 186.0 | 16 | 5 | | | 147 | 63 | 22 | 242 | 46 | 1.04 | 11.72 | 2.24 | 3.04 | 2.83 | 5.0 | 4.1 |
| Dylan Cease | CHW | 33 | 33 | 169.0 | 13 | 8 | | | 144 | 74 | 20 | 230 | 75 | 1.30 | 12.24 | 3.98 | 3.92 | 3.36 | 3.6 | 1.7 |
| Justin Verlander | HOU | 26 | 26 | 162.0 | 16 | 5 | | | 113 | 47 | 22 | 180 | 31 | 0.89 | 10.03 | 1.70 | 2.60 | 3.33 | 3.5 | 4.5 |
| Shane Bieber | CLE | 27 | 27 | 156.0 | 9 | 7 | | | 140 | 58 | 17 | 184 | 42 | 1.16 | 10.58 | 2.41 | 3.34 | 3.06 | 3.4 | 2.8 |
| Shohei Ohtani | LAA | 23 | 23 | 123.0 | 8 | 5 | | | 99 | 44 | 12 | 157 | 39 | 1.12 | 11.46 | 2.82 | 3.24 | 2.95 | 3.1 | 2.4 |
| Tarik Skubal | DET | 30 | 31 | 157.0 | 11 | 9 | | | 143 | 60 | 18 | 172 | 42 | 1.18 | 9.87 | 2.41 | 3.44 | 3.35 | 3.1 | 2.6 |
| Lucas Giolito | CHW | 27 | 27 | 155.0 | 11 | 6 | | | 125 | 58 | 23 | 199 | 50 | 1.13 | 11.60 | 2.93 | 3.36 | 3.51 | 3.1 | 2.7 |
| Frankie Montas | OAK | 31 | 31 | 174.0 | 11 | 10 | | | 150 | 69 | 22 | 191 | 49 | 1.14 | 9.88 | 2.52 | 3.57 | 3.49 | 2.9 | 2.3 |
| Alek Manoah | TOR | 26 | 26 | 145.0 | 12 | 5 | | | 113 | 45 | 13 | 148 | 40 | 1.06 | 9.23 | 2.49 | 2.81 | 3.39 | 2.7 | 3.9 |
| Shane McClanahan | TBR | 29 | 29 | 153.0 | 12 | 7 | | | 124 | 53 | 20 | 197 | 44 | 1.09 | 11.54 | 2.56 | 3.11 | 3.18 | 2.7 | 2.8 |
| Eduardo Rodriguez | DET | 30 | 30 | 156.0 | 9 | 10 | | | 146 | 67 | 16 | 157 | 55 | 1.29 | 9.05 | 3.19 | 3.85 | 3.60 | 2.6 | 1.8 |
| Noah Syndergaard | LAA | 25 | 25 | 139.0 | 10 | 7 | | | 135 | 57 | 15 | 120 | 33 | 1.21 | 7.82 | 2.13 | 3.73 | 3.66 | 2.5 | 1.9 |
| Jameson Taillon | NYY | 28 | 28 | 143.0 | 10 | 6 | | | 141 | 60 | 18 | 128 | 30 | 1.20 | 8.07 | 1.89 | 3.78 | 3.74 | 2.5 | 1.7 |
| Robbie Ray | SEA | 30 | 30 | 180.0 | 12 | 10 | | | 144 | 79 | 28 | 216 | 60 | 1.14 | 10.84 | 3.00 | 3.96 | 3.83 | 2.4 | 1.3 |
| Michael Kopech | CHW | 17 | 33 | 106.0 | 5 | 3 | | | 70 | 32 | 6 | 121 | 50 | 1.13 | 10.22 | 4.23 | 2.67 | 3.14 | 2.4 | 2.7 |
| Jordan Montgomery | NYY | 30 | 30 | 152.0 | 5 | 4 | | | 144 | 63 | 20 | 145 | 36 | 1.18 | 8.55 | 2.10 | 3.71 | 3.73 | 2.4 | 1.9 |
| Patrick Sandoval | LAA | 21 | 23 | 118.0 | 8 | 5 | | | 99 | 41 | 9 | 125 | 50 | 1.26 | 9.52 | 3.80 | 3.15 | 3.38 | 2.3 | 2.4 |
| Nestor Cortes | NYY | 21 | 28 | 124.0 | 6 | 4 | | | 103 | 44 | 17 | 145 | 34 | 1.10 | 10.53 | 2.45 | 3.23 | 3.51 | 2.3 | 2.3 |
| Sonny Gray | MIN | 25 | 25 | 127.0 | 9 | 5 | | | 103 | 47 | 13 | 141 | 48 | 1.19 | 10.03 | 3.43 | 3.33 | 3.46 | 2.3 | 2.3 |
| Joe Ryan | MIN | 24 | 25 | 121.0 | 10 | 6 | | | 97 | 45 | 14 | 123 | 36 | 1.10 | 9.15 | 2.65 | 3.38 | 3.60 | 2.2 | 2.1 |
| Framber Valdez | HOU | 26 | 28 | 158.0 | 12 | 7 | | | 143 | 62 | 11 | 138 | 62 | 1.30 | 7.87 | 3.54 | 3.53 | 3.68 | 2.1 | 2.3 |
| Martín Pérez | TEX | 26 | 32 | 144.0 | 8 | 9 | | | 141 | 57 | 11 | 112 | 47 | 1.30 | 6.97 | 2.91 | 3.58 | 3.70 | 2.1 | 2.0 |
| Zack Greinke | KCR | 31 | 31 | 168.0 | 6 | 9 | | | 181 | 81 | 19 | 109 | 32 | 1.27 | 5.82 | 1.69 | 4.31 | 3.94 | 2.0 | 1.0 |
| Logan Gilbert | SEA | 29 | 29 | 150.0 | 9 | 7 | | | 130 | 59 | 20 | 159 | 47 | 1.18 | 9.54 | 2.84 | 3.57 | 3.81 | 2.0 | 1.8 |
| Luis Severino | NYY | 22 | 23 | 120.0 | 9 | 4 | | | 110 | 46 | 15 | 127 | 33 | 1.19 | 9.55 | 2.45 | 3.47 | 3.60 | 1.9 | 1.9 |
| Chris Paddack | MIN | 22 | 23 | 110.0 | 7 | 7 | | | 111 | 50 | 13 | 104 | 20 | 1.20 | 8.50 | 1.63 | 4.07 | 3.43 | 1.9 | 0.9 |
| Paul Blackburn | OAK | 25 | 27 | 135.0 | 9 | 6 | | | 135 | 55 | 13 | 102 | 32 | 1.24 | 6.80 | 2.12 | 3.68 | 3.64 | 1.9 | 1.5 |
| José Berríos | TOR | 32 | 32 | 183.0 | 11 | 9 | | | 182 | 86 | 26 | 168 | 48 | 1.26 | 8.29 | 2.38 | 4.21 | 4.11 | 1.9 | 1.5 |
| Luis Garcia | HOU | 29 | 30 | 150.0 | 11 | 9 | | | 132 | 64 | 23 | 163 | 50 | 1.21 | 9.75 | 2.99 | 3.85 | 4.01 | 1.8 | 1.4 |