ZiPS Projections Courtesy of Dan Szymborski
| Jacob deGrom | | NYM | 12 | 3 | 1.62 | 25 | 25 | 152.0 | 84 | 27 | 12 | 226 | 23 | 0.71 | 13.43 | 1.36 | 1.71 | 6.9 |
| Zack Wheeler | | PHI | 12 | 8 | 2.83 | 32 | 32 | 207.0 | 173 | 65 | 17 | 235 | 50 | 1.07 | 10.20 | 2.16 | 2.75 | 6.6 |
| Corbin Burnes | | MIL | 9 | 5 | 2.62 | 26 | 30 | 153.0 | 121 | 45 | 8 | 214 | 34 | 1.01 | 12.56 | 2.00 | 1.86 | 6.4 |
| Gerrit Cole | | NYY | 16 | 9 | 3.14 | 33 | 33 | 203.0 | 160 | 71 | 27 | 275 | 46 | 1.01 | 12.17 | 2.02 | 2.89 | 6.1 |
| Brandon Woodruff | | MIL | 11 | 7 | 2.52 | 30 | 30 | 181.0 | 122 | 51 | 15 | 211 | 47 | 0.93 | 10.51 | 2.33 | 2.78 | 5.5 |
| Walker Buehler | | LAD | 15 | 2 | 2.48 | 31 | 31 | 194.0 | 139 | 53 | 20 | 208 | 46 | 0.95 | 9.67 | 2.12 | 3.14 | 5.0 |
| Nathan Eovaldi | | BOS | 12 | 7 | 3.58 | 28 | 28 | 158.0 | 158 | 63 | 9 | 155 | 31 | 1.19 | 8.86 | 1.76 | 2.73 | 4.8 |
| German Marquez | | COL | 12 | 12 | 3.77 | 33 | 33 | 191.0 | 169 | 80 | 19 | 198 | 64 | 1.22 | 9.34 | 3.00 | 3.43 | 4.5 |
| Kevin Gausman | | SFG | 13 | 8 | 2.81 | 31 | 32 | 185.0 | 135 | 58 | 19 | 216 | 56 | 1.03 | 10.48 | 2.73 | 3.12 | 4.3 |
| Carlos Rodon | | CHW | 11 | 7 | 2.79 | 25 | 25 | 141.0 | 104 | 44 | 16 | 194 | 41 | 1.04 | 12.40 | 2.64 | 2.94 | 4.3 |
| Clayton Kershaw | | LAD | 15 | 9 | 3.29 | 27 | 27 | 162.0 | 131 | 59 | 21 | 189 | 29 | 0.99 | 10.53 | 1.63 | 3.08 | 4.2 |
| Lucas Giolito | | CHW | 14 | 10 | 3.57 | 32 | 32 | 191.0 | 153 | 76 | 27 | 229 | 60 | 1.11 | 10.80 | 2.81 | 3.60 | 4.2 |
| Lance Lynn | | CHW | 15 | 6 | 2.64 | 29 | 29 | 168.0 | 134 | 49 | 18 | 188 | 53 | 1.11 | 10.10 | 2.82 | 3.36 | 4.1 |
| Aaron Nola | | PHI | 12 | 9 | 4.09 | 31 | 31 | 183.0 | 169 | 83 | 27 | 220 | 43 | 1.16 | 10.80 | 2.13 | 3.54 | 4.1 |
| Shane Bieber | | CLE | 12 | 7 | 3.40 | 25 | 25 | 160.0 | 142 | 61 | 20 | 216 | 49 | 1.19 | 12.10 | 2.74 | 3.12 | 4.1 |
| Trevor Rogers | | MIA | 11 | 8 | 2.79 | 28 | 29 | 156.0 | 124 | 48 | 10 | 177 | 56 | 1.15 | 10.23 | 3.21 | 2.90 | 4.1 |
| Max Scherzer | | LAD | 13 | 6 | 2.98 | 29 | 29 | 171.0 | 121 | 57 | 27 | 228 | 43 | 0.96 | 12.02 | 2.27 | 3.52 | 3.9 |
| Freddy Peralta | | MIL | 11 | 5 | 2.65 | 26 | 33 | 152.0 | 81 | 45 | 16 | 205 | 67 | 0.98 | 12.13 | 3.97 | 3.29 | 3.8 |
| Sean Manaea | | OAK | 12 | 8 | 3.19 | 29 | 29 | 169.0 | 153 | 60 | 20 | 183 | 40 | 1.14 | 9.72 | 2.14 | 3.35 | 3.8 |
| Tyler Glasnow | | TBR | 8 | 4 | 2.96 | 23 | 23 | 136.0 | 92 | 45 | 16 | 190 | 45 | 1.01 | 12.64 | 2.98 | 2.92 | 3.7 |
| Joe Musgrove | | SDP | 11 | 9 | 3.19 | 29 | 31 | 167.0 | 131 | 59 | 20 | 190 | 41 | 1.03 | 10.23 | 2.23 | 3.44 | 3.7 |
| Jose Berrios | | TOR | 11 | 8 | 3.61 | 31 | 31 | 186.0 | 155 | 75 | 22 | 194 | 51 | 1.11 | 9.37 | 2.48 | 3.66 | 3.5 |
| Julio Urias | | LAD | 16 | 5 | 3.55 | 28 | 35 | 174.0 | 150 | 69 | 24 | 187 | 39 | 1.08 | 9.65 | 2.00 | 3.59 | 3.5 |
| Yu Darvish | | SDP | 11 | 7 | 3.36 | 29 | 29 | 169.0 | 135 | 63 | 23 | 198 | 42 | 1.05 | 10.55 | 2.24 | 3.57 | 3.4 |
| Charlie Morton | | ATL | 14 | 5 | 3.69 | 31 | 31 | 169.0 | 138 | 69 | 17 | 195 | 60 | 1.17 | 10.39 | 3.21 | 3.53 | 3.4 |
| Luis Castillo | | CIN | 9 | 14 | 4.06 | 33 | 33 | 186.0 | 173 | 84 | 19 | 191 | 78 | 1.35 | 9.23 | 3.76 | 3.83 | 3.4 |
| Jordan Montgomery | | NYY | 6 | 7 | 3.83 | 29 | 29 | 153.0 | 139 | 65 | 18 | 153 | 48 | 1.22 | 9.00 | 2.83 | 3.64 | 3.3 |
| Chris Bassitt | | OAK | 14 | 5 | 3.43 | 31 | 32 | 188.0 | 160 | 72 | 22 | 188 | 49 | 1.11 | 9.01 | 2.33 | 3.67 | 3.3 |
| Pablo Lopez | | MIA | 9 | 8 | 3.33 | 29 | 29 | 152.0 | 133 | 56 | 16 | 163 | 39 | 1.13 | 9.64 | 2.33 | 3.39 | 3.2 |
| Marcus Stroman | | NYM | 11 | 11 | 2.94 | 31 | 31 | 168.0 | 152 | 55 | 16 | 140 | 42 | 1.16 | 7.53 | 2.26 | 3.56 | 3.2 |