| 1 | Mariano Rivera | NYY | 12 | 11 | 116 | 191 | 0 | 197.0 | 8.86 | 1.32 | 0.59 | .229 | 85.8% | 52.4% | 8.4% | 94.4 | 1.64 | | 2.56 | 2.71 | 6.7 |
| 2 | Matt Thornton | CHW | 16 | 10 | 13 | 205 | 0 | 200.1 | 11.01 | 2.65 | 0.58 | .282 | 78.3% | 46.8% | 8.1% | 96.3 | 2.70 | | 2.46 | 2.65 | 6.3 |
| 3 | Jonathan Papelbon | BOS | 11 | 12 | 116 | 198 | 0 | 204.1 | 10.09 | 2.64 | 0.70 | .287 | 76.2% | 38.1% | 7.0% | 95.3 | 2.69 | | 2.85 | 3.26 | 5.6 |
| 4 | Heath Bell | SDP | 18 | 11 | 89 | 209 | 0 | 217.2 | 9.76 | 3.31 | 0.37 | .298 | 77.2% | 45.8% | 4.5% | 94.1 | 2.77 | | 2.63 | 3.26 | 5.6 |
| 5 | Jonathan Broxton | LAD | 15 | 13 | 72 | 207 | 0 | 207.1 | 11.94 | 3.65 | 0.43 | .316 | 71.0% | 49.0% | 6.8% | 97.1 | 3.21 | | 2.38 | 2.67 | 5.6 |
| 6 | Brian Wilson | SFG | 11 | 11 | 127 | 201 | 0 | 209.1 | 10.45 | 3.48 | 0.56 | .313 | 77.4% | 48.7% | 6.8% | 96.7 | 2.97 | | 2.82 | 3.17 | 5.3 |
| 7 | Carlos Marmol | CHC | 6 | 11 | 60 | 238 | 0 | 239.0 | 12.99 | 5.95 | 0.49 | .233 | 77.9% | 35.2% | 5.4% | 94.8 | 2.86 | | 3.23 | 3.83 | 5.0 |
| 8 | Joakim Soria | KCR | 6 | 7 | 115 | 176 | 0 | 186.0 | 9.97 | 2.47 | 0.68 | .259 | 88.5% | 44.5% | 7.6% | 91.9 | 1.84 | | 2.85 | 3.14 | 4.9 |
| 9 | Hong-Chih Kuo | LAD | 10 | 4 | 13 | 130 | 0 | 159.1 | 10.79 | 2.60 | 0.34 | .246 | 82.7% | 42.2% | 3.9% | 94.7 | 1.75 | | 2.18 | 2.90 | 4.7 |
| 10 | Mike Adams | SDP | 6 | 4 | 0 | 161 | 0 | 169.0 | 10.22 | 2.66 | 0.53 | .246 | 81.6% | 43.3% | 6.1% | 93.0 | 1.81 | | 2.49 | 2.97 | 4.3 |
| 11 | Rafael Soriano | - - - | 4 | 9 | 75 | 155 | 0 | 152.0 | 10.36 | 2.96 | 0.65 | .235 | 78.6% | 30.8% | 5.9% | 93.3 | 2.43 | | 2.78 | 3.38 | 3.8 |
| 12 | Francisco Rodriguez | - - - | 9 | 11 | 122 | 199 | 0 | 193.2 | 10.08 | 4.32 | 0.65 | .278 | 78.4% | 39.7% | 6.9% | 92.7 | 2.74 | | 3.32 | 3.73 | 3.7 |
| 13 | Joe Nathan | MIN | 3 | 4 | 86 | 138 | 0 | 136.1 | 10.76 | 2.64 | 0.79 | .233 | 89.1% | 44.1% | 9.4% | 94.4 | 1.72 | | 2.84 | 2.93 | 3.6 |
| 14 | Darren Oliver | - - - | 13 | 4 | 1 | 180 | 0 | 202.2 | 7.90 | 2.31 | 0.62 | .291 | 79.3% | 46.5% | 7.0% | 89.9 | 2.71 | | 3.18 | 3.56 | 3.6 |
| 15 | Billy Wagner | - - - | 8 | 4 | 64 | 133 | 0 | 132.0 | 12.41 | 2.73 | 0.68 | .244 | 79.6% | 36.5% | 7.9% | 95.8 | 1.77 | | 2.33 | 2.57 | 3.5 |
| 16 | Andrew Bailey | OAK | 7 | 6 | 51 | 115 | 0 | 132.1 | 9.05 | 2.52 | 0.54 | .225 | 87.3% | 41.1% | 5.4% | 94.8 | 1.70 | | 2.70 | 3.36 | 3.4 |
| 17 | Luke Gregerson | SDP | 6 | 11 | 3 | 152 | 0 | 153.1 | 10.68 | 2.88 | 0.65 | .266 | 70.3% | 47.0% | 8.4% | 91.7 | 3.23 | | 2.68 | 2.83 | 3.3 |
| 18 | Takashi Saito | - - - | 9 | 10 | 21 | 157 | 0 | 156.2 | 10.40 | 3.33 | 0.63 | .299 | 80.8% | 39.5% | 6.1% | 92.5 | 2.59 | | 2.95 | 3.51 | 3.1 |
| 19 | Neftali Feliz | TEX | 5 | 3 | 42 | 90 | 0 | 100.1 | 9.87 | 2.33 | 0.63 | .209 | 78.6% | 37.2% | 5.8% | 97.5 | 2.42 | | 2.81 | 3.41 | 3.0 |
| 20 | Scott Downs | TOR | 6 | 11 | 14 | 181 | 0 | 178.2 | 7.46 | 2.72 | 0.50 | .269 | 80.7% | 60.2% | 7.9% | 90.5 | 2.42 | | 3.25 | 3.42 | 2.9 |
| 21 | Arthur Rhodes | - - - | 9 | 6 | 2 | 197 | 0 | 143.2 | 8.65 | 3.38 | 0.44 | .255 | 80.4% | 35.6% | 4.4% | 92.3 | 2.32 | | 2.98 | 3.76 | 2.9 |
| 22 | Sergio Romo | SFG | 13 | 6 | 2 | 142 | 0 | 130.0 | 9.97 | 2.28 | 0.69 | .252 | 74.8% | 33.5% | 5.8% | 89.7 | 2.63 | | 2.83 | 3.50 | 2.9 |
| 23 | Darren O'Day | - - - | 8 | 4 | 2 | 170 | 0 | 164.0 | 7.13 | 2.41 | 0.55 | .262 | 78.0% | 43.8% | 5.6% | 87.6 | 2.63 | | 3.37 | 3.96 | 2.6 |
| 24 | Joba Chamberlain | NYY | 4 | 6 | 3 | 104 | 0 | 107.2 | 10.20 | 3.01 | 0.59 | .319 | 71.1% | 49.7% | 6.9% | 95.9 | 3.68 | | 2.71 | 3.03 | 2.4 |
| 25 | J.P. Howell | TBR | 13 | 6 | 20 | 133 | 0 | 156.0 | 9.87 | 4.15 | 0.75 | .249 | 80.7% | 51.8% | 10.7% | 83.8 | 2.48 | | 3.53 | 3.47 | 2.3 |
| 26 | Ramon Ramirez | - - - | 11 | 9 | 4 | 210 | 0 | 210.2 | 7.18 | 3.84 | 0.68 | .256 | 79.1% | 38.6% | 6.1% | 93.5 | 2.82 | | 3.83 | 4.45 | 2.3 |
| 27 | Daniel Bard | BOS | 3 | 4 | 4 | 122 | 0 | 124.0 | 10.09 | 3.77 | 0.80 | .250 | 79.2% | 46.0% | 9.8% | 98.0 | 2.61 | | 3.38 | 3.36 | 2.0 |
| 28 | Craig Breslow | - - - | 12 | 13 | 6 | 201 | 0 | 191.1 | 7.76 | 3.62 | 0.85 | .229 | 76.9% | 33.5% | 7.1% | 91.0 | 2.87 | | 3.85 | 4.32 | 1.8 |
| 29 | Brad Ziegler | OAK | 8 | 11 | 18 | 180 | 0 | 193.2 | 5.81 | 3.62 | 0.37 | .300 | 81.2% | 60.5% | 6.3% | 85.5 | 2.51 | | 3.63 | 3.93 | 1.7 |
| 30 | Clay Hensley | - - - | 4 | 5 | 7 | 99 | 0 | 109.0 | 8.34 | 4.29 | 0.25 | .271 | 72.9% | 52.2% | 3.2% | 89.7 | 2.89 | | 3.17 | 3.88 | 1.5 |