| 1 | Miles Mikolas | STL | 12 | 13 | 0 | 33 | 32 | 202.1 | 6.81 | 1.73 | 1.11 | .249 | 74.4% | 45.0% | 11.9% | 93.6 | 3.29 | 3.89 | 3.87 | 3.80 | 2.8 |
| 2 | Justin Verlander | HOU | 18 | 4 | 0 | 28 | 28 | 175.0 | 9.51 | 1.49 | 0.62 | .240 | 80.5% | 37.9% | 6.2% | 95.1 | 1.75 | 2.66 | 2.49 | 3.23 | 6.1 |
| 3 | Jordan Lyles | BAL | 12 | 11 | 0 | 32 | 32 | 179.0 | 7.24 | 2.61 | 1.31 | .313 | 73.8% | 40.2% | 11.4% | 91.9 | 4.42 | 4.94 | 4.40 | 4.39 | 1.4 |
| 4 | Martin Perez | TEX | 12 | 8 | 0 | 32 | 32 | 196.1 | 7.75 | 3.16 | 0.50 | .295 | 77.0% | 51.4% | 6.5% | 92.9 | 2.89 | 3.59 | 3.27 | 3.80 | 3.8 |
| 5 | Charlie Morton | ATL | 9 | 6 | 0 | 31 | 31 | 172.0 | 10.73 | 3.30 | 1.47 | .292 | 76.0% | 39.8% | 16.5% | 94.9 | 4.34 | 4.11 | 4.26 | 3.60 | 1.5 |
| 6 | Alek Manoah | TOR | 16 | 7 | 0 | 31 | 31 | 196.2 | 8.24 | 2.33 | 0.73 | .244 | 82.6% | 37.5% | 7.1% | 93.9 | 2.24 | 3.31 | 3.35 | 3.97 | 4.1 |
| 7 | Corey Kluber | TBR | 10 | 10 | 0 | 31 | 31 | 164.0 | 7.63 | 1.15 | 1.10 | .317 | 70.2% | 36.1% | 9.3% | 89.1 | 4.34 | 4.00 | 3.57 | 3.92 | 3.0 |
| 8 | Adam Wainwright | STL | 11 | 12 | 0 | 32 | 32 | 191.2 | 6.71 | 2.54 | 0.75 | .302 | 75.0% | 43.2% | 8.1% | 88.1 | 3.71 | 4.53 | 3.66 | 4.10 | 2.8 |
| 9 | Logan Gilbert | SEA | 13 | 6 | 0 | 32 | 32 | 185.2 | 8.43 | 2.38 | 0.92 | .292 | 77.6% | 36.7% | 9.2% | 96.1 | 3.20 | 4.11 | 3.46 | 3.78 | 3.2 |
| 10 | Shane McClanahan | TBR | 12 | 8 | 0 | 28 | 28 | 166.1 | 10.50 | 2.06 | 1.03 | .251 | 80.5% | 50.2% | 15.7% | 97.0 | 2.54 | 2.79 | 3.00 | 2.60 | 3.5 |
| 11 | Shohei Ohtani | LAA | 15 | 9 | 0 | 28 | 28 | 166.0 | 11.87 | 2.39 | 0.76 | .289 | 83.1% | 41.9% | 9.3% | 97.4 | 2.33 | 2.68 | 2.40 | 2.65 | 5.6 |
| 12 | Kyle Wright | ATL | 21 | 5 | 0 | 30 | 30 | 180.1 | 8.68 | 2.65 | 0.95 | .284 | 78.9% | 55.6% | 14.4% | 95.1 | 3.19 | 3.89 | 3.58 | 3.30 | 2.9 |
| 13 | Shane Bieber | CLE | 13 | 8 | 0 | 31 | 31 | 200.0 | 8.91 | 1.62 | 0.81 | .287 | 75.8% | 48.2% | 10.4% | 91.5 | 2.88 | 3.51 | 2.87 | 2.98 | 4.9 |
| 14 | Corbin Burnes | MIL | 12 | 8 | 0 | 33 | 33 | 202.0 | 10.83 | 2.27 | 1.02 | .259 | 76.8% | 47.0% | 14.1% | 96.2 | 2.94 | 3.05 | 3.14 | 2.85 | 4.6 |
| 15 | Cal Quantrill | CLE | 15 | 5 | 0 | 32 | 32 | 186.1 | 6.18 | 2.27 | 1.01 | .278 | 76.4% | 42.1% | 9.6% | 93.9 | 3.38 | 4.31 | 4.12 | 4.39 | 2.2 |
| 16 | Zac Gallen | ARI | 12 | 4 | 0 | 31 | 31 | 184.0 | 9.39 | 2.30 | 0.73 | .237 | 78.0% | 46.0% | 9.1% | 93.9 | 2.54 | 3.17 | 3.05 | 3.31 | 4.3 |
| 17 | Cole Irvin | OAK | 9 | 13 | 0 | 30 | 30 | 181.0 | 6.36 | 1.79 | 1.24 | .273 | 71.4% | 37.7% | 10.5% | 90.9 | 3.98 | 4.40 | 4.21 | 4.35 | 1.4 |
| 18 | Sandy Alcantara | MIA | 14 | 9 | 0 | 32 | 32 | 228.2 | 8.15 | 1.97 | 0.63 | .262 | 78.8% | 53.4% | 8.5% | 98.0 | 2.28 | 2.92 | 2.99 | 3.29 | 5.7 |
| 19 | Dylan Cease | CHW | 14 | 8 | 0 | 32 | 32 | 184.0 | 11.10 | 3.82 | 0.78 | .260 | 82.3% | 38.8% | 8.4% | 96.9 | 2.20 | 2.70 | 3.10 | 3.50 | 4.4 |
| 20 | Jose Urquidy | HOU | 13 | 8 | 0 | 29 | 28 | 164.1 | 7.34 | 2.08 | 1.59 | .264 | 78.9% | 36.0% | 12.9% | 93.6 | 3.94 | 4.56 | 4.60 | 4.32 | 1.1 |
| 21 | Triston McKenzie | CLE | 11 | 11 | 0 | 31 | 30 | 191.1 | 8.94 | 2.07 | 1.18 | .237 | 80.3% | 32.7% | 10.3% | 92.7 | 2.96 | 3.54 | 3.59 | 3.77 | 3.6 |
| 22 | Logan Webb | SFG | 15 | 9 | 0 | 32 | 32 | 192.1 | 7.63 | 2.29 | 0.51 | .293 | 71.8% | 56.7% | 8.3% | 92.4 | 2.90 | 3.59 | 3.03 | 3.31 | 4.2 |
| 23 | Framber Valdez | HOU | 17 | 6 | 0 | 31 | 31 | 201.1 | 8.67 | 3.00 | 0.49 | .285 | 75.7% | 66.5% | 12.5% | 94.0 | 2.82 | 3.31 | 3.06 | 2.99 | 4.4 |
| 24 | Pablo Lopez | MIA | 10 | 10 | 0 | 32 | 32 | 180.0 | 8.70 | 2.65 | 1.05 | .283 | 74.2% | 46.1% | 12.7% | 93.5 | 3.75 | 3.75 | 3.71 | 3.56 | 2.8 |
| 25 | Jordan Montgomery | - - - | 9 | 6 | 0 | 32 | 32 | 178.1 | 7.97 | 1.82 | 1.06 | .275 | 75.5% | 47.6% | 13.0% | 93.1 | 3.48 | 4.00 | 3.61 | 3.43 | 2.7 |
| 26 | Kyle Freeland | COL | 9 | 11 | 0 | 31 | 31 | 174.2 | 6.75 | 2.73 | 0.98 | .318 | 70.5% | 42.0% | 9.5% | 90.4 | 4.53 | 5.11 | 4.21 | 4.48 | 2.6 |
| 27 | Aaron Nola | PHI | 11 | 13 | 0 | 32 | 32 | 205.0 | 10.32 | 1.27 | 0.83 | .289 | 73.0% | 43.6% | 9.8% | 92.9 | 3.25 | 2.74 | 2.58 | 2.77 | 6.3 |
| 28 | Carlos Rodon | SFG | 14 | 8 | 0 | 31 | 31 | 178.0 | 11.98 | 2.63 | 0.61 | .293 | 75.1% | 34.1% | 6.5% | 95.5 | 2.88 | 2.64 | 2.25 | 2.91 | 6.2 |
| 29 | Marco Gonzales | SEA | 10 | 15 | 0 | 32 | 32 | 183.0 | 5.07 | 2.46 | 1.48 | .277 | 73.7% | 42.0% | 12.3% | 88.7 | 4.13 | 4.59 | 5.05 | 4.90 | 0.1 |
| 30 | Nick Pivetta | BOS | 10 | 12 | 0 | 33 | 33 | 179.2 | 8.77 | 3.66 | 1.35 | .300 | 75.3% | 38.5% | 12.4% | 93.6 | 4.56 | 4.65 | 4.42 | 4.26 | 1.5 |